中西医结合治疗类风湿性关节炎继发骨质疏松的疗效观察

The rheumatoid arthritis and secondary osteoporosis in patients with the use of traditional Chinese medicine combined with western medicine treatment of the clinical effect

目的研究类风湿性关节炎(RA)继发骨质疏松(OP)的患者运用中药联合西药治疗的临床效果。方法我院选择2010年5月-2012年5月间诊治的68例类风湿关节炎继发骨质疏松的患者,将其随机分为两组,对照组的34例患者运用鲑鱼降钙素喷鼻剂,碳酸钙D3片,连续治疗2个月;观察组的34例患者以上治疗的基础上加用中药补肾治疗,同样治疗2个月;经过治疗后,比较两组患者的症状改善情况、临床治疗效果、骨密度(BMD)以及体征等变化。结果两组患者经过治疗后,观察组患者的总有效率为91.2%,对照组为73.6%;观察组明显优于对照组,两组差异显著,有统计学意义(P<0.05)。观察组患者的关节压痛指数、晨僵时间、关节肿胀指数以及关节功能指数改善情况均明显优于对照组,两组患者差异显著,有统计学意义(P<0.05)。经过治疗后,观察组患者的Ca及BMD等指标均比治疗前明显提高,ESR指标比治疗前明显降低,治疗前后差异显著,有统计学意义(P<0.05),同时两组患者治疗后指标比较,差异显著,有统计学意义(P<0.05)。结论类风湿性关节炎继发骨质疏松的患者运用中西医结合治疗的临床效果显著,能够很好的调节骨代谢情况,应在临床上大力推广使用。

Objective To study the rheumatoid arthritis （ RA） and secondary osteoporosis （ OP） in patients with the use of traditional Chinese medicine combined with western medicine treatment of the clinical effect.Method in our hospital from May 2010-2012 year in May 68 cases of rheumatoid arthritis with secondary osteoporosis patients, randomly divided into two groups, 34 patients in the control group using salmon calcitonin nasal spray and TanSuanGaiD3Pian sustained-release tablets, 2 in a row month treatment;the observation group were treated with above treatment of tonifying kidney, the same 2 months of treatment; after treatment, compared two groups of patients with symptoms, clinical treatment, bone mineral density and signs.Results the two groups of patients after treatment, the patients in observation group the total efficiency is 91.2%, control group 73.6%; the observation group was better than the control group, the two groups had significant difference, with statistical significance （ P〈0.05）.The patients in observation group joint pain index, time of morning stiffness, joint swelling index and joint function indexes were significantly better than the control group, the differences between the two groups were significant, with statistical significance （P〈0.05）.After treatment, the patients in the observation group were Ca and BMD were significantly improved than before treatment, ESR index was significantly lower than before treatment,before and after the treatment were significant, with statistical significance （ P〈0.05 ） , while the two group patients after index comparison, difference, with statistical significance （ P〈0.05）.Conclusion rheumatoid arthritis secondary osteoporosis patients with combination of traditional Chinese medicine combined with Western medicine treatment of the clinical effect is significant, can regulate bone metabolism is very good, it should be popularized in clinical use.