有创-无创序贯机械通气治疗AECOPD合并Ⅱ型呼吸衰竭的临床疗效分析

Clinical effect of sequential invasive and non-invasive mechanical ventilation in treatment of AECOPD combined with type Ⅱ respiratory failure

目的探讨有创-无创序贯机械通气治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并Ⅱ型呼吸衰竭的临床疗效。方法随机选取AECOPD合并Ⅱ型呼吸衰竭患者64例,按照就诊先后顺序半随机分为治疗组(32例)和对照组(32例),在常规治疗基础上,治疗组采用无创序贯通气治疗,对照组采用常规有创通气治疗,观察两组主要通气指标变化情况。结果治疗组总通气时间少于对照组(P<0.05),呼吸机相关性肺炎(VAP)发生率低于对照组(P<0.05)。结论有创-无创序贯性机械通气治疗AECOPD合并Ⅱ型呼吸衰竭临床疗效显著,缩短通气时间,降低VAP发生率,具有良好的临床应用价值,值得推广。

Objective To observe the clinical effect of sequential invasive and non-invasive mechanical ven-tilation in treatment of acute exacerbation of chronic obstructive pulmonary disease （ AECOPD） combined with type Ⅱrespiratory failure .Methods Sixty-four patients with AECOPD combined with type Ⅱrespiratory failure in our hos-pital were randomly selected and divided into two groups .On the basis of routine treatment ,32 patients in the treat-ment group were given sequential non-invasive ventilation and another 32 patients in the control group were given con-vention ventilation respectively .The main ventilation index were compared .Results Compared with the control group,the total ventilation time was significant shorter and the incidence of ventilator -associated pneumonia （ VAP） was significant lower in the treatment group （ P〈0.05 ） .Conclusion The sequential invasive and non-invasive venti-lation in treatment of AECOPD combined with type Ⅱrespiratory failure has better clinical effect , shortening the total ventilation time and reducing the incidence of VAP .It is of certain clinical value and is worth popularizing .