类叶升麻苷在大鼠体内的药代动力学及组织分布研究

Pharmacokinetics and tissue distribution of acteoside in rats

目的研究类叶升麻苷(acteoside)在大鼠体内的药代动力学及组织分布特征。方法大鼠灌胃给予300 mg·kg-1的类叶升麻苷后,采用HPLC检测各时间点血浆和组织器官药物浓度,并用DAS2.0软件计算药代动力学参数。结果大鼠灌胃给药后,药时曲线符合二室开放模型,主要药动参数分布半衰期T12α、消除半衰期T12β、曲线下面积AUC、血浆清除率CL分别为:2.37 h、2.916 h、1.031μg·L-1·h、306.241 L·h-1。结论类叶升麻苷体内吸收符合一级动力学,主要分布在肠、肺脏、脾脏组织中,在所研究的组织中未见特殊蓄积现象。

Aim To study the pharmaeokineties and tissue distribution of aeteoside in rats. Method The plasma and tissue concentration of aeteoside was detec- ted by HPLC method after intragastrie administration of 300 mg · kg 1 aeteoside. The pharmaeokineties was calculated by the procedure of DAS 2. 0. Results The concentration-time curves conformend to two-com- partment model. The pharmaeokinetie parameters T1α/2 , T1/2 β, AUC, and CL were 2.37 h, 2. 916 h, 1. 031 μg · L 1 .h, and 306. 241 L·h 1, respectively. Con- clusion After intragastrie administration of aeteoside, the in vivo absorption of aeteoside meets the standard of first-order kinetics and aeteoside is mainly distributed in intestine, lung and spleen tissues. There is no long- term accumulation of aeteoside in rats tissues.