基于PAPI-PDLLA仿生骨组织工程材料表面亲/疏水及降解性能的研究

Research on the biomimetic bone tissue engineering materials PAPI-PDLLA of physical and chemical properties

考察材料表面亲/疏水性能和降解性能是评价其能否适用于生物医学领域的重要指标。主要从材料表面静态水接触角和吸水率综合评价PAPI-PDLLA的表面亲/疏水性,从材料降解过程中失重率测定、分子量测定、pH值变化和表面形貌观察综合评价PAPIPDLLA的降解性能。实验结果表明,通过调节亲水嵌段聚(乙二醇-co-均苯四甲酸酐)亚胺(PAPI)在材料中占的比重,可以调节材料的亲/疏水性能,并且还可缓解PDLLA降解过程中出现的酸性积累问题。因而,PAPIPDLLA已具备应用于生物医学领域的基础。

Investigation of the surface hydrophilic/hydrophobic properties and degradation properties was to e-valuate material can be applied to biomedical field.PAPI-PDLLA surface hydrophilic/hydrophobic was evalua-ted by the material surface static water contact angle and water absorption comprehensive.PAPI - PDLLA degradation property was characterized by determination of weight-loss ratio,molecular weight,pH,surface morphology.Experimental results show that,the degradation of PDLLA performance by adj usting the hydro-philic block PAPI accounted for the proportion in the material,and adj usting the hydrophilic/hydrophobic prop-erties,and it also can ease the PDLLA appeared in the process of degradation of acid accumulation problem. Therefore,PAPI-PDLLA will be applied in the field of biomedical.