水热法调控羟基磷灰石微结构研究进展

A review of hydroxyapatite microstructure regulation with hydrothermal method

羟基磷灰石由于具有优良的生物相容性和生物活性而被广泛应用于骨组织修复和替代领域。而磷灰石的不同微观结构对其力学性能和生物学性能具有较大的影响,因此对其微结构的控制显得至关重要。水热法是人为构建高温高压的密闭环境,通过添加Ca源和P源,在较为极端的条件下合成具有较高的结晶性磷灰石晶粒。受仿生矿化的影响,高分子有机物由于具有磷灰石定向沉积的活性基团,因而被用于水热法制备形貌新颖的磷灰石粒子。综述了近年来不同种类有机物模板运用于水热法的制备方法,探讨了有机物调控磷灰石晶粒形貌和尺寸的规律以及展望了水热法制备羟基磷灰石发展趋势。

Due to the excellent biocompatibility and bioactivity,hydroxyapatite （HA）has been widely used in the fields of bone repair and substitute.However,the different microstructure has a great influence on the me-chanical properties and biological properties,so it is critical to control the morphology and microstructure of HA.Hydrothermal method is an artificial environment of high temperature and high pressure,by adding Ca and P sources,synthetic crystalline apatite grains have higher crystallinity in the extreme conditions.Affected by bi-omimetic mineralization,organic polymer can be used in preparing novel morphology of apatite particles by hy-drothermal method due to a mount of active groups for apatite orientated deposition.This paper summarized the methods of HA preparation by hydrothermal method using different kinds of organic template in recent years, and discussed the mechanism of organic template to control apatite grain size and morphology and forecasted the development trend of it.