吡拉格雷钠与阿司匹林联用对脑缺血再灌注损伤的保护研究

Protection on cerebral ischemia/reperfusion injury of the combination of tetramethylpyrazine-2'-O-sodium ferulate and aspirin

目的观察吡拉格雷钠和阿司匹林联合用药对小鼠血小板聚集功能的影响,以及对脑缺血再灌注损伤大鼠的保护作用。方法采用玻片法和小鼠断尾法,测定联合用药对其出血时间(BT)和凝血时间(CT)的影响;应用大鼠局灶性脑缺血再灌注损伤模型,评测联合用药对大鼠神经功能、脑含水量和脑梗死灶体积的影响。结果与空白对照组及单独用药组相比,联合用药组显著延长出凝血时间、改善脑缺血再灌注损伤大鼠神经功能、降低脑含水量并减小脑梗死灶体积。结论吡拉格雷钠和阿司匹林联合用药比单独用药具有更显著的抗血小板聚集作用,并对大鼠脑缺血再灌注损伤有更显著保护作用。

Objective To observe the effect on platelet aggregation of the combination of tetramethylpyrazine-2＆#39;-O-sodium ferulate （TSF）and aspirin in mice,and its protection effect on cerebral ischemia/reperfusion injury （CIRI）in rats.Methods Observe the effect of the combined administration on bleeding time and coagulation time by slide method and tail cut method;Focal cerebral ischemia/reperfusion model was achieved in rats.After that,neurological deficit score evaluation,brain water content and infarct volume were measured.Results Compared with control group and single-drug group,the combination group significantly prolonged bleeding time and coagulation time.At the same time,the combination group significantly improved the neurological function of CIRI rats.It also reduced the brain water content and infarct volume of the brain.Conclusion The combination of TSF and aspirin has a more significant effect on anti-platelet aggregation than the sole use of each medicine,and a more significant effect on cerebral ischemia/reperfusion injury in rats.