纳洛酮对急性酒精中毒患者抗氧化能力状态影响的研究

Study of influence of naloxone on the antioxidant capacity of patients with acute alcoholism

目的探讨纳洛酮对急性酒精中毒患者抗氧化能力状态的影响。方法将本院2012年2月～2014年1月收治的60例急性酒精中毒患者随机分为治疗组和对照组，每组各30例。对照组给予常规治疗，治疗组在对照组的基础上给予纳洛酮治疗，比较两组患者治疗前后的抗氧化能力。结果两组治疗24h后，TAC、CAT均上升，但治疗组的上升幅度明显高于对照组；MDA、LPO均降低，但是治疗组的降低幅度明显大于对照组（P〈0．05）。两组的不良反应发生率比较．差异无统计学意义（P〉0．05）。结论纳洛酮对急性酒精中毒患者的抗氧化能力状态影响较大。可改善患者的预后。

Objective To explore the influence of naloxone on the antioxidant capacity of patients with acute alcoholism. Methods 60 patients with acute alcoholism were treated in our hospital from February 2012 to January 2014, and they were randomly divided into treatment group and the control group,there were 30 cases in each group,the control group was given conventional treatment,the treatment group was given naloxone on the basis of the control group, the antioxidant capacity of the two groups before and after treatment were compared. Results After 24 hours treatment, the TAC,CAT increased,but the rise in treatment group was obviously higher than that of the control group;MDA and LPO decreased,but the reduction in the treatment group was obviously greater than the control group （P〈0.05）. There was no statistical difference of the incidence rate of adverse reactions in the two groups （P〉0.05）. Conclusion The influence of naloxone on the antioxidant capacity of patients with acute alcoholism bigger, it can improve the prognosis of patients.