低分子肝素钙联合氨溴索、小青龙汤对喘息性支气管炎患者血清CRP、TNF-α的影响

Influence of Low Molecular Heparin Calcium Combined with Ambroxol and Small Qinglong Decoction of Serum CRP and TNF-Αin Patients with Asthmatic Bronchitis

目的:分析低分子肝素钙联合氨溴索对喘息性支气管炎患者血清CRP、TNF-α的影响。方法:回顾性分析我院2011年3月—2013年4月期间收治的78例喘息性支气管炎患者的临床资料,将其平均分成对照组与治疗组,给予对照组采用常规抗感染与激素治疗,治疗组在对照组的基础上采用低分子肝素钙雾化吸入联合氨溴索静脉滴注、小青龙汤加减治疗,比较两组患者血清C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)及治疗效果。结果:治疗后两组患者血清CRP和TNF-α都有显著下降,但治疗组下降更明显,两组相比差异具有统计学意义(P<0.05)。治疗组和对照组患者的喘息缓解时间、喘鸣音消失时间、湿罗音消失时间、咳嗽消失时间比较,差异明显,具有统计学意义(P<0.05)。且治疗组的治疗总有效率为94.9%(37/39),对照组的治疗总有效率为79.5%(31/39),两组疗效相比差异明显,具有统计学意义(P<0.05)。结论:低分子肝素钙联合氨溴索治疗喘息性支气管炎患者,疗效显著,可有效调节患者血清CRP的表达,改善TNF-α对患者身体的不良影响,促进患者早日康复,值得临床推广应用。

Objective： To analyze the low molecular heparin calcium combined with ambroxol and small Qinglong Decoction of asthmatic bronchitis in patients with serum CRP and its influence of TNF alpha. Methods： 78 cases of patients with asthmatic bronchitis in March 2011 to April 2013 were divided into control group and treatment group. The control group used conventional anti-infection and hormone treatment and the treatment group on the basis of conventional therapy added low molecular heparin calcium atomization inhalation combined with ambroxol and small Qinglong Decoction. The serum c-reactive protein（ CRP）,tumor necrosis factor alpha（ TNF alpha） and the therapeutic effect in two groups were compared. Results： The two groups＇ serum CRP and TNF alpha had been dropped significantly,but the treatment group＇s decreased more significantly and two groups had statistically significant difference（ P 〈 0. 05）. The breathing ease time,wheezing disappear time and wet rale disappearing time and cough disappeared time in two groups had obvious differences（ P 〈0. 05）. And the treatment group＇s total effective rate was 94.9%（ 37 /39） and the control group＇s was 79. 5%（ 31 /39） and there was statistical significance（ P 〈 0. 05）. Conclusion： Low molecular heparin calcium combined with ambroxol and small Qinglong Decoction for patients with asthmatic bronchitis has significant curative effect,and can effectively regulate serum CRP,improve the bad influence of TNF alpha on patient＇s body,promote patients recover at an early date,and it is worthy of clinical popularization and application.