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Acupuncture and moxibustion reduces neuronal edema in Alzheimer's disease rats 被引量:10

Acupuncture and moxibustion reduces neuronal edema in Alzheimer's disease rats
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摘要 To examine the possible correlation of aberrant Wnt signaling and pathological changes in Alzheimer’s disease, we established a rat model of Alzheimer’s disease and measured axin and β-catenin expression in the hippocampus. Rats were pretreated with moxibustion or electroacu-puncture, or both, at Baihui(GV20) and Shenshu(BL23). Axin expression was lower, β-catenin expression was greater, and neuronal cytoplasmic edema was visibly prevented in the rats that had received the pretreatments. Our results suggest that the mechanism underlying the neuro-protective effect of acupuncture and moxibustion in Alzheimer’s disease is associated with axin and β-catenin expression in the Wnt signal transduction pathway. To examine the possible correlation of aberrant Wnt signaling and pathological changes in Alzheimer’s disease, we established a rat model of Alzheimer’s disease and measured axin and β-catenin expression in the hippocampus. Rats were pretreated with moxibustion or electroacu-puncture, or both, at Baihui(GV20) and Shenshu(BL23). Axin expression was lower, β-catenin expression was greater, and neuronal cytoplasmic edema was visibly prevented in the rats that had received the pretreatments. Our results suggest that the mechanism underlying the neuro-protective effect of acupuncture and moxibustion in Alzheimer’s disease is associated with axin and β-catenin expression in the Wnt signal transduction pathway.
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第9期968-972,共5页 中国神经再生研究(英文版)
基金 supported by the National Natural Science Foundation of China,No.30772837 the Wuhan Municipal"Morning Sun"Science and Technology Plan,No.200850731347
关键词 nerve regeneration brain injury acupuncture and moxibustion pretreatment Alzheimer’s disease AXIN β-catenin NSFC grant neural regeneration nerve regeneration brain injury acupuncture and moxibustion pretreatment Alzheimer’s disease axin β-catenin NSFC grant neural regeneration
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