血清Hcy、CysC、尿β2–MG联合检测对早期糖尿病肾病的诊断价值

Clinical significance of detection of serum homocysteine,cystatin C and urine β2-microglobulin in diagnosis of early diagnosis of diabetic nephropathy

目的探讨血清同型半胱氨酸(Hcy)、血清胱抑素C(CysC)和尿β2-微球蛋白(β2-MG)联合检测对2型糖尿病早期肾病诊断的临床价值。方法检测119例2型糖尿病患者按尿液清蛋白排泄率分为A、B、C组:正常清蛋白组(A组,n=48),微量清蛋白组(B组,n=37),大量清蛋白组(C组,n=34),同时采用50例健康人作为健康对照组。分别检测Hcy、CysC、尿β2-MG水平,对检测结果进行统计学分析。结果糖尿病患者各组间血清Hcy、CysC、尿β2-MG水平检测结果比较差异均有统计学意义(P<0.05)。结论血清Hcy、CysC、尿β2-MG联合检测可以推断糖尿病肾病的损害程度,提示临床应早期干预血清同型半胱氨酸水平,几项指标联合检测在糖尿病肾病早期诊断中有较高的临床应用价值。

Objective To explore application of serum homocysteine,cystatin C and urine β2- microglobulin joint detection in diagnosis of diabetic nephropathy.Methods The 119 cases with diabetic nephropathy according to urinary albumin excretion rates：were divided into Group A（48 cases） with normal albumin,Group B（37 cases） with albumin,Group C（34 cases）with large amounts of albumin.At the same time,50 healthy subjects were enrolled as normal control group.Serum homocysteine,serum cystatin C,urine β2-microglobulin levels were detected and analyzed by using SPSS software.Results Serum homocysteine,serum cystatin C,urine β2- microglobulin between diabetic nephropathy groups were statistically different（P0.05）.Conclusions The detection of serum homocysteine,serum cystatin C and urine β2-microglobulin can evaluate renal damage in diabetes patients,for early clinical intervention of serum homocysteine levels.Joint detection of Hcy、CysC and urine β2-MG is a sensitive and reliable for method for early diagnosis of diabetic nephropathy.