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Toll样受体2功能的研究进展 被引量:5

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摘要 Toll样受体(Toll-like receptors,TLR)是一种模式识别受体(pattern recognition receptor,PRR),主要识别来源于微生物的具有保守结构的病原体相关分子模式(pathogen-associated molecular patterns,PAMP),激发机体的免疫反应,在机体抗病原体感染中发挥重要作用.最早在果蝇体内发现TLR,迄今为止在哺乳动物中已发现13种TLR,在人类至少发现10种TLR,包括TLR1~ 10.
出处 《中华生物医学工程杂志》 CAS 2014年第1期71-74,共4页 Chinese Journal of Biomedical Engineering
基金 青海省自然科学基金(2011-Z-932Q)
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参考文献36

  • 1Agrawal S,Kandimalla ER.Medicinal chemistry and therapeutic potential ofCpG DNA[J].Trends Mol Med,2002,8:114-121.
  • 2杨芳芳,陈成水.Toll样受体2的研究进展[J].医学综述,2008,14(11):1636-1639. 被引量:13
  • 3Qiu Y,Shen Y,Li X,et al.Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88(MyD88)[J].Dev Comp Inmunol,2008,32:1522-1530.
  • 4Edfeldt K,Swedenborg J,Hansson GK,et al.Expression of toll-like receptors in human atherosclerotic lesions:a possible pathway for plaque activation[J].Circulation,2002,105:1158-1161.
  • 5Scholtes VP,Versteeg D,de Vries JP,et al.Toll-like receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis[J].Clin Sci(Lond),2011,121:205-214.
  • 6Zou L,Feng Y,Chen YJ,et al.Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis.Crit Care Med,2010,38:1335-1342.
  • 7Ha T,Lu C,Liu L,et al.TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism[J].Am J Physiol Heart Circ Physiol,2010,298:H984-H991.
  • 8Versteeg D,Hoefer IE,Schoneveld AH,et al.Monocyte toll-like receptor 2 and 4 responses and expression following percutaneous coronary intervention:association with lesion stenosis and fractional flow reserve[J].Heart,2008,94:770-776.
  • 9Arslan F,Smeets MB,O'Neill LA,et al.Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody[J].Circulation,2010,121:80-90.
  • 10Mersmann J,Koch A,Tran N,et al.Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion[J].Crit Care Med,2010,38:1927-1932.

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