缺铁性贫血治疗前后听性脑干反应的变化

The effects of iron supplementation on auditory brain-stem response with iron deficiency anemia in rats

目的 :探讨缺铁性贫血导致感音神经性聋的治疗方法及疗效。方法 :将 6 8只 Wistar大鼠分成 3组 :48只通过缺铁饮食制作缺铁性贫血模型 ,缺铁 A组和 B组各 2 4只 ;另设标准对照 C组正常大鼠 2 0只。将 A、B两组进行缺铁饲养 6周 ,检测听性脑干反应 (ABR) ,每组各随机取样 10只检测畸变产物耳声发射 (DPOAE) ,再分别给予铁剂加高压氧治疗和单纯铁剂治疗。结果 :缺铁 Wistar大鼠经 6周饲养 ,较实验前 ABR听觉阈值提高和 波 PL 延长 ,经过两种不同方案治疗 6周 ,均取得明显效果 (P<0 .0 5 ) ,但两组差异无显著性。结论 :对于缺铁性贫血造成感音神经性耳聋 ,早期给予及时的铁剂治疗疗效好 ,而高压氧用于治疗此类耳聋并非必要。

Objective:To evaluate the therapeutic methods of sensorineural hearing loss with iron deficiency anemia and their effects.Method:Sixty eight Wistar rats were randomly divided into 3 groups: Group A (iron deficiency group A) 24 rats, group B (iron deficiency group B) 24 rats and group C (control group) 20 rats. Group A and B were fed with iron deficiency diet for 6 weeks.By analyzing ABR and DPOAE, hearing loss was detected in group A and B. Then,group A was given iron supplementation diet and hyperbaric oxygen therapies, and group B was given iron supplementation diet only. Result:The auditory thresholds and period latencies (PL) of I waves of ABR and DPOAE amplitude in 2 kHz and 3kHz within group A and B were significantly different before and after treatment (P< 0.05 ). But the effects of treatment between these two groups had not significant differences (P> 0.05 ).Conclusion:It suggested that good results can be obtained by early iron supplementation in iron deficiency hearing loss cases. Hyperbaric Oxygen therapy may not be necessary.