摘要
探讨成人糖尿病胰岛功能减退的原因。将成人糖尿病患者 92例分为A组 (5 0例 ,胰岛功能良好 )和B组(4 2例 ,胰岛功能较差 )。A组中 ,A1组 30例 ,用正规治疗控制血糖 ;A2 组 2 0例 ,未用正规治疗控制血糖。B组中 ,B1组 2 2例 ,在饮食控制、运动疗法基础上加用胰岛素控制血糖 ;B2 组 2 0例 ,在同样基础上加用磺脲类药物控制血糖。疗程均为 3- 5年。结果表明 :A1组血糖得到控制 ,A2 组胰岛功能减退 ;B1组胰岛功能恢复至正常 ,B2 组胰岛功能未得到改善。胰岛素水平分析 ,A2 与A1,A2 与A ,B2 与B1,B1与B对比 ,P均小于 0 .0 1;A1与A ,B2 与B对比 ,P均大于 0 .0 5。成人糖尿病胰岛功能减退的原因有 :(1)高血糖的毒性作用。 (2 )胰岛功能较差时应用磺脲类药物 ,加重了存活胰岛 β细胞分泌负担 ,使胰岛
To study the cause of hypoinsulinism,92 cases of adult diabetics were divided into two groups: group A(50 patients), whose function of islets of pancreas were normal,and group B(42 patients), who had hypoinsulinism.In group A, the patients in group A 1(30 patients) were treated by regular therapy to control blood glucose,but the patients in group A 2(20 patients)were not.In group B,based on the dietotherapy and motortherapy,grup B 1(22 patients)was treated by insulin to control blood glucose,while group B 2(20 patients)was treated by sulfaurea drugs to control blood glucose.The courses of treatment of both groups(group A and B)were 3-5 years.After the treatment,the blood glucose of group A 1 was controled,but the function of islets of pancreas of group A 2 was deteriorated;the function of islests of pancreas of group B 1 was recovered to normal, but the function of islets of pancreas of geoup B 2 had no improvement.In the analysis of insulin levels,A 2 vs A 1,A 2 vs A,B 2 vs B 1,B 1 vs B were statistically significant( P <0.01), while A 1 vs A, B 2 vs B were not( P< 0.05). So the cause of hypoinsulinism are: (1) the toxic action of hyperglycosemia; (2)the use of sulfaurea drugs make the survival islet β cells overloaded and deteriorated.
出处
《标记免疫分析与临床》
CAS
2001年第1期3-5,共3页
Labeled Immunoassays and Clinical Medicine