绝经后骨质疏松症与血清IL-6,TNF-α浓度关系的临床研究

Relationship between postmenopausal osteoporosis and serum IL-6 and TNF-α levels

目的 研究绝经后骨质疏松症与血清IL - 6及TNF -α浓度关系。方法 选择绝经后骨质疏松患者 30例 ,采用Elisa检测其血清中IL - 6 ,TNF -α水平 ,并与正常青年妇女对照。 结果绝经后骨质疏松症患者IL - 6 ,TNF -α水平较正常组明显升高 (P均 <0 0 1)。且与骨密度呈负相关。结论 绝经后雌激素减少 ,导致末梢血单核细胞产生的IL - 6及TNF -α等细胞因子过量 ,而IL- 6及TNF -α过量分泌会刺激破骨细胞性骨吸收活性 ,导致骨质疏松症的发生。

Objective\ To study the relationship between postmenopausal osteoporosis and serum IL-6 and TNF-α levels. Methods\ Serum IL-6 and TNF-α levels in 30 patients with postmenopausal osteoporosis were measured by ELISA,and compared with those in 30 healthy women. Results\ The serum IL-6 and TNF-α levels in the patients were significantly higher than those in the healthy women( P <0 01).At the same time,the serum IL-6 and TNF-α levels were negatively correlated with bone mineral density. Conclusion\ Postmenopausal diminution of estrogen may bring about escessive secretion of IL-6 and TNF-α by peripheral blood mononuclear leucocytes while IL-6 and TNF-α stimulate osteoclastic bone resorption. \;