期刊文献+

铝盐致大鼠学习记忆功能障碍的β-APP、SS作用机制研究 被引量:3

The roles of β APP and SS in the deficits of learning and memory function in rats due to subcutaneous injection of aluminum salt
下载PDF
导出
摘要 目的 观察 β淀粉样前体蛋白 (APP)、生长抑素 (SS)在铝盐致大鼠学习记忆功能障碍模型脑内海马区表达的改变 ,并探讨其作用机制。方法 采用免疫组织化学方法检测 β- APP、SS在大鼠脑内海马区的表达 ,HE染色观察实验组与对照组海马区锥体细胞层神经元形态结构。结果 实验组大鼠学习记忆功能较对照组明显降低 (P<0 .0 1) ;实验组海马区 β- APP表达较对照组明显增加 (P<0 .0 1) ;SS免疫反应性神经元数目却显著减少 (P<0 .0 1) ;β- APP阳性度与 SS阳性度之间存在等级负相关 (P<0 .0 5 ) ,实验组与对照组海马区神经元形态结构均基本正常 ,数目无明显差异。结论 铝盐致大鼠学习记忆障碍的病理机制可能与脑内β- APP。 Objective To observe the expression of β APP and SS in the hippocampus of the rat mode ls with the deficits of learning and memory function, and investigate its mechanism.Methods Using immunohistochemistry (IHC), we detected the expressions of β amyloid precursorprotein(β APP) and somatostatin(SS) in the hippocampus of the rat brains,using HE staining method, we observed the shapes and structures of pyramidal cell layer neurons in hippocampus of the rats in the experimental group and the controls.Results The learning and memory functions were lower significantly in the experimental group than in the controls ( P <0.01);The expression of β APP in hippocampus of experimental group was significantly higher than the controls ( P <0.01);but the number of SS immunoreactive positive neurons decreased sigificantly ( P <0.01); There was negative relation between the positive degrees of β APP and SS in the experimental group ( P <0.05).The structures of neurons in hippocampus of the experimental group and the controls were fundamental normal,there was no significant difference between the numbers of their neurons.Conclusion The pathogenesis of aluminum slat resulted in the deficits of learning and memory functions in rats,it might be related to the changes of the expressions of β APP and SS in brain.
出处 《临床神经病学杂志》 CAS 2001年第1期24-26,共3页 Journal of Clinical Neurology
关键词 Β-淀粉样前体蛋白 生长抑素 学习记忆 Aluminum β amyloid precursor protein Somatostatin Learning and memory
  • 引文网络
  • 相关文献

参考文献3

二级参考文献8

共引文献108

同被引文献31

  • 1杨新华,周萍,李勇辉.铅暴露对大鼠学习和记忆的影响[J].中国临床心理学杂志,2007,15(1):88-91. 被引量:4
  • 2[11]Lamirault L,Guillou JL,Micheau J,et al,Intrahippocampal injection of somatostin dissociate acquisition from the flexible use of place resonses[J].Eur J Neurosci,2001,14:567.
  • 3[12]Rostampour M,Fathollahi Y,Semnania S,et al.The ability of hi-ppocampal CA1 area for induction of long-term potention is persisitently reduced by prior treatment with cysteaminea:an intro study[J].Neuropeptides,2002,36:263.
  • 4[1]Ellis MR,Kane KY.Lightening the lead load in children[J].Am Fam Physician,2000,62:545.
  • 5[2]Dykeman R,Aguilar-Madrid G,Smith Hernandez-Avila M.Lead e-xposure in Mexican radiator repair workers[J].Am J Ind Med,2002,41:179.
  • 6[3]Ma T,Chen HH,Ho IK.Effects of chronic lead (Pb) exposure on neurobehavioral function and dopaminergic neurotransmitter receptors in rats[J].Toxicol Lett,1999,105:111.
  • 7[6]Scortegagna M,Hanbauer I.The effect of lead exposure and serum deprivation on mesencephalic primary cultures[J].Neurotoxicology,1997,18:331.
  • 8[7]Shafer TJ.Effects of Ca2+Pb2+ and ch3hg+ on high voltage activated calcium currents in pheochromocytoma cells:potency reversibility interactions with extracellular Ca2+ and mechanisms of block[J].Toxicol Lett,1998,99:207.
  • 9HOLLOSI M , URGE L , PERCZEL A, et al. Metalion-induced conformational changes of phosphorylated fragments of human neurofilament ( NF-M ) protein [ J ]. J Mol Biol , 1992 , 223 ( 3 ): 673-682.
  • 10FORLONI G, CH1ESA R, SMIROLDO S, et al. Apoptosis mediated neuro-toxicity induced by chronic application of beta amyloid fragment 25-35[ J ]. Neuroreport, 1993, 4( 5 ): 523-526.

引证文献3

二级引证文献14

;
使用帮助 返回顶部