摘要
目的 :研究萘丁美酮对小鼠免疫功能的影响。方法 :小鼠灌胃萘丁美酮后 ,分别观察胸腺、脾脏重量 ,腹腔巨噬细胞吞噬功能和游走功能 ,体内PHA诱导的淋巴细胞转化。结果 :萘丁美酮能明显减轻小鼠胸腺和脾脏重量 ,降低小鼠腹腔巨噬细胞吞噬游走功能 ,抑制PHA诱导的小鼠淋巴细胞转化。结论 :萘丁美酮对小鼠细胞免疫功能有明显的抑制作用。
AIM:To study the effects of nabumetone on immunological fuctions in mice METHODS:After nabumetone was given ig to mice,the weight of thymus and spleen,phagocytizing function of macrophages,PHA-induced lymphocyte transformation were observed respectively in mice RESULTS:The weight of thymus and spleen was decreased,the phagocytizing function of macrophages was reduced,PHA-induced lymphocyte transformation was markedly inhibited with nabumetone in mice CONCLUSION:The immunological function in mice was significantly inhibited with nonsteriod anti-inflammatory drug-nabumetone
出处
《中国药房》
CAS
CSCD
2001年第5期269-269,共1页
China Pharmacy
关键词
萘丁美酮
免疫功能
巨噬细胞
淋巴细胞转化
药理
nabumetone
immunological function
macrophages
lymphocyte transformation