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萘丁美酮对小鼠免疫功能的影响 被引量:3

Effects of Nabumetone on Immunological Functions in Mice
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摘要 目的 :研究萘丁美酮对小鼠免疫功能的影响。方法 :小鼠灌胃萘丁美酮后 ,分别观察胸腺、脾脏重量 ,腹腔巨噬细胞吞噬功能和游走功能 ,体内PHA诱导的淋巴细胞转化。结果 :萘丁美酮能明显减轻小鼠胸腺和脾脏重量 ,降低小鼠腹腔巨噬细胞吞噬游走功能 ,抑制PHA诱导的小鼠淋巴细胞转化。结论 :萘丁美酮对小鼠细胞免疫功能有明显的抑制作用。 AIM:To study the effects of nabumetone on immunological fuctions in mice METHODS:After nabumetone was given ig to mice,the weight of thymus and spleen,phagocytizing function of macrophages,PHA-induced lymphocyte transformation were observed respectively in mice RESULTS:The weight of thymus and spleen was decreased,the phagocytizing function of macrophages was reduced,PHA-induced lymphocyte transformation was markedly inhibited with nabumetone in mice CONCLUSION:The immunological function in mice was significantly inhibited with nonsteriod anti-inflammatory drug-nabumetone
出处 《中国药房》 CAS CSCD 2001年第5期269-269,共1页 China Pharmacy
关键词 萘丁美酮 免疫功能 巨噬细胞 淋巴细胞转化 药理 nabumetone immunological function macrophages lymphocyte transformation
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  • 1陈奇.中药药理研究方法学[M].北京:人民卫生出版社,1994.362、757.
  • 2Liu D,Razzaque MS,Cheng M,et al.The renal expression of heat shock protein 47 and collagens in acute and chronic experimental diabetes in rats[J].Histochem J,2001,33(11-12):621-628.
  • 3Fan JM,Ng YY,Hill PA,et al.Transforming growth factor-beta regulates tubular epithelial myofibroblast transdifferentiation in vitro[J].Kidney Int,1999,56(4):1455-1467.
  • 4Li JH,Zhu HJ,Huang XR,et al.Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation[J].J Am Soc Nephrol,2002,13(6):1464-1672.
  • 5Jones S.Regulation of renal proximal tubular epithelial cell hyaluronan generation:Implications for diabetic nephropathy[J].Kidney Int,2001,59(5):1739-1749.
  • 6Wang SN,Hirschberg R,Growth factor ultrafiltration in experimental diabetic nephropathy contributes to interstitial fibrosis[J].Am J Physiol Renal Physiol,2000,278(4):F554-560.
  • 7Faust J, Menke J, Kriegsmann J, et al. Epithelialcell-derived interleukin-18 up-regulation with disease activity in MRL-Fas lpr mice with autoimmune lupus nephritis[J]. Arthritis Rheum, 2002, 46 (11):3083 - 3095.
  • 8Liu D, Razzaque MS, Cheng M, et al. The renal expression of heat shock protein 47 and collagens in acute and chronic experimental diabetes in rats[J]. Histochem J, 2001 , 33(11 - 12): 621 -628.
  • 9Fan JM, Ng YY, Hill PA, et al. Transforming growth factor-beta regulates tubular epithelial myofibroblast transdifferentiation in vitro [J].Kidney Int, 1999, 56(4): 1455 - 1467.
  • 10Li JH, Zhu HJ, Huang XR, et al. Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation[J]. JAm Soc Nephrol, 2002, 13(6): 1464 -1472.

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