脑血管病患者神经肽Y的临床研究

A clinical study on levels of neuropeptide Y in plasma in patients with cerebrovascular disease

目的 观察脑出血 (CH)、脑梗死 (CI)、蛛网膜下腔出血 (SAH)患者神经肽 Y(NPY)水平动态变化及其临床意义。方法 选择脑血管病 (CVD)患者 138例 ,其中 CH组 46例 ,CI组 6 2例 ,SAH组 30例。用放免法检测血浆 NPY浓度。结果 CI组、CH组、SAH组 NPY水平显著高于对照组 ,于发病后 2 4h内均显著升高 ,1～3d或 4～ 7d达高峰 ,8～ 15 d开始下降 ,15 d后仍在较高水平 ;重型与大灶组显著高于中、轻型与小灶组 ;发病积分≥6分组显著高于 <6分组 ,伴高血压组显著高于不伴高血压 ;伴消化道出血组显著高于不伴消化道出血组。结论 NPY参与了

Objective To investigate levels of neuropeptide Y in plasma and the clinical significance in patients with cerebral hemorrhage and cerebral infarction and subarachnoid hemorrhage. Methods The levels of neuropeptide Y in plasma were measured by radioimmunoassay in 138 cases with cerebrovascular disease and 28 healthy control subjects. 138 patients were divided into cerebral hemorrhage group (46 cases). cerebral infarction group (62 cases)and subarachnoid hemorrhage group(30 cases).Results The levels of neuropeptide Y in plasma in the three groups were higher than that in control group. The levels of neuropeptide Y in plasma in the three groups started to increase significantly during the first day,and reached peak on day 1d to 3d or 4d to 7d.They began to decrease from the eighth day. The levels of neuropeptide Y were higher than that in control group after 15 days. The severer the condition of cerebral hemorrhage and cerebral infarction, the higher the neuropeptide Y levels. There was a significant correlation between plasma levels of neuropeptide Y and some complicated diseases of cerebral infarction, cerebral hemorrhage and subarachnoid hemorrhage.Conclusion Neuropeptide Y play a major role in pathophysiological and pathogenetic mechanisms of cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage and some complicated diseases.