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腺苷蛋氨酸对妊娠肝内胆汁淤积症的临床观察 被引量:10

Effect of S-adenosy-L-mathionine in intrahepatic cholestasis of pregnancy
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摘要 目的 评估腺苷蛋氨酸治疗妊娠肝内胆汁淤积症 (ICP)的效果。方法 观察组 30例采用腺苷蛋氨酸治疗 ,对照组 30例采用苦黄注射液治疗 ,治疗 3周后观察肝功能、瘙痒评分。两组病人在孕 32周后行NST检查 ,分娩后比较两组围生儿预后及产妇预后情况。结果 观察组血清总胆红素 (TBIL)、直接胆红素 (DBIL)、血清总胆汁酸 (TBA)、碱性磷酸酶 (ALP)、血清总胆固醇 (CHOL)及瘙痒评分明显下降 ,与对照组比较差异有显著性意义 (P <0 0 1) ,观察组产时缺氧发生率低 ,且孕周较长、新生儿体重较重 ,剖宫产率较低 (P <0 0 5 )。 Objective To observe the effect of S-adenosy-L-methionine in intrahepatic cholestasis of pregnancy.Methods Sixty cases of intrahepatic cholestasis of pregnancy have been chosen and randomly divided into 2 groups:S-adenosy-L-methionine group and Kuhuang group.After 3 weeks' treatment,the liver function and itch score were observed.The non-stress test(NST) were carried out after 32 weeks of gestation.The prognosis of newborns and mothers were investigated.Results Make a comparison after treatment between the two groups,there were significant differences in TBIL,DBIL,ALP,CHOL,TBA and Grade of itch(P<0 01);the incidence of fetal distress and neonatal asphyxia were decraesed in S-adenosy-L-methionine group(P<0 01).Meanwhile,pregnancy period was prolonged and weight of newborns were increased.Conclusion S-adenosy-L-methionine is a good drug in the treatment of intrahepatic cholestasis of pregnancy.
出处 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 2001年第6期343-344,共2页 Chinese Journal of Practical Gynecology and Obstetrics
关键词 腺苷蛋氨酸 肝内胆汁淤积症 妊娠合并症 S-adenosy-L-methionine Intrahepatic cholestasis of pregnancy
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