摘要
目的 确证降糖药那格列奈另一种新的晶型结构 ,称为S型。给出X射线衍射、红外图谱和相关数据。方法 用X射线粉末衍射、红外光谱、元素分析和差示扫描量热法作物相分析。结果 S型那格列奈有与文献报道的H型、B型完全不同的晶型。mp 172 0 4℃。
AIM To find a new crystal structure of S form in nateglinide [ N (trans 4 isopropylcyclohexylcarbonyl) D phenylalanine]. The XRD, IR patterns and data were given and the melting point was determined. METHODS Phase analysis was performed by X ray powder diffraction, IR and elemental analysis and the melting point was determined by differential scan calorimetry. RESULTS S form nateglinide is different from H form or B form. The melting point is 172 04℃. CONCLUSION The S form nateglinide is a new crystal form.
出处
《药学学报》
CAS
CSCD
北大核心
2001年第7期532-534,共3页
Acta Pharmaceutica Sinica
基金
SupportedbytheresearchfundfromJiangsuProvinceKeyLabofDrugDeliverySystem (DDS2 0 0 10 1)
JiangsuProvinceEducationCommittee
