国产长春瑞宾联合顺铂治疗晚期非小细胞肺癌36例分析

Short term effect of vinorelbine on non - small cell lung cancer in 36 cases

目的:评价国产长春瑞宾（盖诺,VNB）联合顺铂治疗晚期非小细胞肺癌化疗方案的疗效。方法:有明确的病理和/或细胞学诊断的36例晚期非小细胞肺癌患者,运用盖诺25mg/m2d1,8;PDD100mg/m2分3天静脉滴注,同时配合水化利尿、碱化尿液。每21天为一周期,化疗中记录毒副反应,三周期为一疗程,然后评价其疗效。结果:CR0例,PR15例,NC20例,PD1例,有效率为41.6％（15/36）。不良反应主要为骨髓抑制和消化反应。结论:国产长春瑞宾和顺铂联合方案治疗晚期非小细胞肺癌,疗效较高且毒副反应可以耐受。

Objective: To evaluate effect of vinorelbine(VNB) and cisplatin on non-small cell lung cancer(NSCLC).Methods: 36 cases of cytologically and pathologically confirmed advanced NSCLC were treated with combined chemotherapy including navelbine and cisplatin. VNB 25mg/m2 Ⅳ, day 1 and day 8, PDD 3 days a total of 100mg/m Ⅳ, a cycle was 21 days. Effect has been evalu-tated after 3 cycles. All patients received no previous treatment. Results:There was no CR in patients treated with the regimen, PR was 15 in 36 cases( 41.6%), NC was 20 cases( 55.6%) and PD 1 case( 2.8%). The side effects were mainly myleosuppression and digestive tract rection. Conclusion:Result showed that the combined chemotherapy was effective and safe in the treatment of advanced NSCLC.