吗氯贝胺治疗抑郁症的双盲双模拟试验研究

Test of moclobemide for depressions in a double-blind experimence

目的 :评价吗氯贝胺的抗抑郁疗效和不良反应。方法 :选用阿米替林作为对照药 ,进行双盲对照。对 3 8例抑郁症患者(吗氯贝胺组 17例 ,双盲阿米替林组 2 1例 )作为期 8周的治疗。服药前后均作汉密尔顿抑郁量表 ( HAMD) ,临床疗效总评量表( CGI) ,副反应量表 ( TESS)及实验室检查和精神检查等。结果 :吗氯贝胺的抗胆碱能不良反应明显少于阿米替林组 ( P<0 .0 5 )。结论

OBJECTIVE: To evaluate the effect and side effect of Moclobemide for depressions. METHODS: In a double blind experimence,Amitriptyline was selected as controls,38 depressions took treatment for 8 weeks (17 subjects treated by Moclobemide,21 subjects treated by Amitriptyline). All of them were evaluated by HAMD, CGI, TESS, laboratory examination and mental examination. RESULTS: There was no difference between Moclobemide and Amitriptyline for depression,but side effects of Moclobemide were less than those of Amitriptyline. CONCLUSION: This double blind experimence indicated that Moclobemide is a new safe, effective medicine for depression.