系统性红斑狼疮累及中枢神经系统的临床分析(附93例报告)

The analysis of central nervous system involvement in systemic lupus erythematosus

目的 对系统性红斑狼疮（ＳＬＥ）的中枢神经系统（ＣＮＳ）病变特点及临床预后进行总结。方法 对９３例伴有中枢神经系统损害的ＳＬＥ患者进行回顾性分析。结果①ＳＬＥ的ＣＮＳ损害症状可分为以下几类：弥漫性症状（４０．９％）、局灶性症状（２３．７％）。抽搐（２４．７％）、头痛（１０．８％）。②局灶性症状的患者预后明显差于弥漫性症状者，抽搐和头痛患者的预后与弥漫性症状患者类似。③脑脊液蛋白增高及ＣＮＳ损害发生早的患者预后差。结论本组ＳＬＥ患者ＣＮＳ受累的症状分布与国外报道类似，不同症状患者的预后情况有明显差异。

Objective To investigate the symptoms and prognosis of systemic lupus eiythematosus( SLE) with central vous system( CNS) involvement. Methods The clinical data of 93 SLE patients with CNS involvement were retrospectively re- viewed in our hospital. Results ①The symptoms were classified as diffuse manifestations(51 .6%), focal manifestations(23.7%), seizures(24.7%) and headache 00. 8%). ②The prognosis of focal manifestations was significantly worse than that of diffuse manifestations. Seizures had the similar prognosis as diffuse manifestations. ③The other two poor prognosis factors were ele- vated by cerebralspinal fluid protein level and SLE duration for≤2 years’at CNS involvement. Conclusions The characteristics of CNS symptoms in SLE in our patients is similar to the overseas reports. The prognosis is significantly related to clinical features in CNS.