黄芪注射液改善脑梗死病人红细胞流变性剂量效应的观察

Dose-effect of Astragalus membrana-ceus injection on rheological properties of red blood cells

目的 :探讨黄芪对脑梗死病人红细胞流变行为影响的剂量 效应关系。方法 :脑梗死病人 60例 ,分为 4组 (各 15例 )。在常规治疗的基础上 ,各组每日分别加用黄芪注射液 10 ,2 0 ,3 0 ,40mL ,iv ,gtt× 10d。测定治疗前后病人红细胞变形、聚集指数的变化及病情变化。结果 :与 10mL组比较 ,2 0mL组各项指数P >0 .0 5 ,3 0 ,40mL组红细胞变形指数分别为 0 .9± 0 .3 ,0 .9± 0 .3 ,较治疗前显著升高 (P <0 .0 1)、聚集指数分别为 (2 .0± 0 .3 ,2 .0±0 .4) ,较治疗前显著下降 (P <0 .0 1) ,临床总有效率均为 93 %较 10 ,2 0mL组 (分别为 60 % ,67% )显著升高 (P <0 .0 5 )。 3 0mL组和 40mL组间各项指标均无显著差异。结论 :黄芪对脑梗死病人红细胞流变性的影响存在着剂量 效应关系 ,每日静脉滴注黄芪注射液 3 0mL最为适宜。

AIM:To investigate the dose effect relation of Astragalus membranaceus and erythrocyte hemorheology. METHODS: Sixty patients with acute cerebral infarction were equally divided into four groups. Based on conventional treatment, the patients were given Astragalus membranaceus injection 10,20,30 mL and 40 mL in each group respectively, iv,drip,qd for 10 d. Before and after treatment, the indexes of erythrocyte deformability and erythocyte aggregation were detected and the degree of neurological deficits were studies. RESULTS: When compared with 10 mL group, every studied index in 20 mL gorup had no significant change, but the index of erythrocyte deformability increased and index of erythrocyte aggregation decreased significantly in 30 mL and 40 mL groups. Total effective rate of 30 mL group as well as that of 40 mL group was significantly higher than that of 10 mL group. There was no significant difference between 30 mL and 40 mL group in every examined index. CONCLUSION: There is dose effect relation on Astragalus membranaceus and rheological parameters of erythrocytes. Astragalus membranaceus injection 30 mL (equal to crude drug 60 g) per day is an optimum dose for therapy.