摘要
目的 通过对颈椎后纵韧带增殖细胞核抗原 (PCNA)免疫组化的定位研究来探讨后纵韧带肥厚的发生机制。方法 前路减压术分别从 2 3例颈椎间盘突出症 (CDH) ,脊髓型颈椎病(CSM) ,颈椎创伤 (CVT)患者不同部位的后纵韧带切取部份组织作 HE染色及 PCNA单克隆抗体免疫组化染色。结果 5例颈椎间盘突出症 (CDH)患者在运动终板处后纵韧带细胞均有 PCNA高表达 ,在椎间盘及椎体处 13例脊髓型颈椎病 (CSM)患者中只有 2例出现 PCNA高表达 ,5例颈椎创伤 (CVT)中 2例出现 PCNA高表达。
Objective To explore the developmental mechanism of hypertrophy of the posterior longitudinal ligament by examing the immunolocalization of the proliferating cell nuclear antigen in the posterior longitudinal ligament of the cervical spine.Methods One piece of posterior longitudinal ligament tissues in different place from patients with cervical spondylotic myelopathy,cervical disc herniation,and cervical vertebrae trauma(fractures and dislocations of the cervical spine)was extirpated during anterior decompression surgery in the cervical spine,midsagittally sectioned and were stained with an antibody against the proliferating cell nuclear antigen.Results Proliferating cell nuclear antigen in posterior longitudinal ligament tissues were highly expressed in all 5 cases with cervical disc herniation at disc level,in 2 of 13 cases with cervical spondylotic myelopathy,in 2 of 5 cases with cervical vertebrae trauma at disc and/or spine level.Conclusions Mechanical and/or inflammatory stimulation caused by the extruded nucleus pulposus or fracture fragament may contribute to the development of hypertrophy of the posterior longitudinal ligament.
出处
《颈腰痛杂志》
2001年第3期181-183,共3页
The Journal of Cervicodynia and Lumbodynia
关键词
后纵韧带
颈椎
增殖细胞核抗原
posterior longitudinal ligament
cervical vertebrae
PCNA