心康口服液对大鼠异丙肾上腺素性心肌损伤的保护作用

Study on the Protective Effect of Xinkang Oral Liquid on the Isoproterenol-induced Ischemic Myocardial Damage in Rats

目的:探讨心康口服液对缺血心肌损伤的保护作用。方法:皮下注射异丙肾上腺素85mg/kg,造成大鼠缺血心肌损伤模型,并检测各组大鼠血中内皮素(ET)、超氧化物歧化酶(SOD)、丙二醛(MDA)、肌酸激酶(CK)、乳酸脱氢酶(LDH)的含量。结果:心康口服液组大鼠血中ET、MDA、CK、LDH含量明显低于模型组(P<0.01或0.05),SOD含量明显高于模型组(P<0.01);心康口服液组CK含量明显低于舒心口服液组(P<0.01),SOD含量明显高于舒心组(P<0.01)。结论:心康口服液能很好地预防缺血性心肌损伤。

Objetive: To study the protective effect of Xinkang oral liquid on the ischemic myocardial damage. Methods: Ischemic my-ocardial damage model was obtained by ip 85 mg/kg isproterenol. The level of superoxide dismutase(SOD), malodialdehyde(MDA), creatine kinase(CK),lactic dehydrogenase(LDH) in the serum and endothelin (ET) in the plasma were detected. Results: The level of ET, MDA, CK, LDH of Xinkang oral liquid group was much lower than that of model group (P < 0.01). The SOD activity was higher than that of model group (P< 0.01). The level of Xinkang oral liquid group was lower than that of Shuxin oral liquid group. The SOD activity of Xinkang oral liquid group was much higher than that of Shuxin oral liquid group(P < 0.01). Conclusion: Xinkang oral liquid can prevent the myocardium from ischemic damage.