狼疮平颗粒剂对大鼠的长期毒性研究

Long-term Toxic Effects of Langchuangping Granulae on Rats

目的 为狼疮平颗粒剂临床应用的安全性提供毒理学依据。方法 经口给大鼠染毒 5 0 0mg·kg- 1 体重 ,1 5 0 0mg·kg- 1 体重和 5 0 0 0mg·kg- 1 体重的狼疮平颗粒剂 90天 ,观察大鼠的生长发育情况 ,测定血液学及血液生化指标 ,对其重要脏器作组织病理学检查。结果 当给药剂量达 5 0 0 0mg·kg- 1 体重时 ,狼疮平颗粒剂对大鼠生长发育、食物利用率、外周血WBC +DC、RBC、Hb及血清中GPT、GOT、TP、BUN、Crea均未产生任何有生物学意义的损害作用 ,组织病理学检查 ,亦未对心、肝、脾、肺、肾、胸腺等主要脏器产生损害效应。结论 大鼠经口染毒 5 0 0 0mg·kg- 1 体重狼疮平颗粒剂

Objective To evaluate safety of Langchuangping(LCP) granulae on rats. Methods The rats were administered LCP (dose in 500?1500 and 5000 mg·kg -1 weight) by gavage for 90 days. Growth of rats was observed Indices of hematology and blood biochemistry were determined Histopathological observation of some important organs were examined. Results All the indices,such as growth,food availability and WBC+DC,RBC,Hb in blood, as well as GPT,GOT,TP,BUN and Crea in serum were no significant changes.At the same time,no harmful changes were found in histopathological examination of heart,liver,spleen,lung,kidney and thymus. Conclusion At the dosage of 5000 mg·kg -1 , LCP couldn't induce any long-term toxic effects on rats .