摘要
对15例房间隔缺损,19例室间隔缺损儿童进行了血浆心钠素(ANP),心脏指数(CI)和钠排泄分数(FENa%)相关性的研究。结果表明:34例先天性心脏病患儿血浆ANP水平明显高于正常对照组(217.23+83.04 VS 17.51±6.55)P<0.01。CI则明显低于正常对照组(3.32±0.35 VS 4.06±0.33)P<0.05。FENa%与正常对照组比较无明显差别(0.37±0.06 VS 0.38±0.07)P>0.05;34例患儿血浆ANP水平与CI呈负相关(r=-0.75,P<0.05)。提示:房室间隔缺损患儿血浆ANP水平可用来估价该类患儿的心功能。本组患儿血浆ANP水平升高同时FENa%正常,这一现象可能与机体ANP受体的再调节有关。
The plasma atrial natriuretic polypeptide(ANP) of 34 patients with atrial septal defect(ADS) and ventricular septal defect (VSD) were studied. The results showed that the congental heart disease group's plasma ANP were significant higher than the control (P<0.05), cardiac index(CI) significant lower(P<0.05). Nevertheless the fraction execretion natrium (FENa%) had no signifcant difference between the two. The results above demonstrate that the higher plasma ANP might occur when cardiac insufficiencey exsting and the cardiac function might be know by plasma ANP concentration measurement and the natriuresis might not occur by increasing slowly plasma ANT concentration.
关键词
心钠素
心脏指数
心脏缺损
钠
Aatrial Natriuretic Polypeptid
Cardiac Index
Fraction Execretion Natrium
Atrial Septal Defect
Ventricular Septal Defect