果糖二磷酸钠镁对心肌缺血大鼠血流动力学的影响

Effects of sodium magnesium fructose diphosphate on hemodynamics in myocardial ischemia rats

目的：观察果糖二磷酸钠镁（ＦＤＰＭ）对心肌缺血大鼠血流动力学作用。方法：采用垂体后叶素诱发大鼠急性心肌缺血，经ＭＰＡ－Ｖ，型多道生物信号分析系统监测血流动力学变化。结果：（１）给垂体后叶素后，ＭＡＰ、ＬＶＥＤＰ 升高，ＩＴ延长，ＨＲ、＋ｄＰ／ｄｔｍａｘ、－ｄＰ／ｄｔｍａｘ、Ｖｃｅ－５ｋＰａ降低；（２）ＦＤＰＭ升高降低的＋ｄＰ／ｄｔｍａｘ、－ｄＰ／ｄｔｍａｘ及Ｖｃｅ－５ｋＰａ，降低升高的ＬＶＥＤＰ，同时降低ＭＡＰ和减慢ＨＲ；该作用具有剂量依赖性。结论：ＦＤＰＭ能改善心肌缺血大鼠的血流动力学。

Objective To investigate the effect of sodium magnesium frutose diphosphate (FDPM) on hemodynarntcs in myocardial ischernia rats. l'tiethods : Acute myocardial ischemia model were induced by pituitrin in rats, and then hemodynamic variables were monitored with multichannel biological signal analytical system. Results: After administation of pituitrin MAP and LVEDP were increased, IT was prolonged, HR. + dP/dtmax, - dP/ dtmax, and Vce - 5kPa were simultaneously decreased. Alter i. v. bolus injection of FDPM, + dP/dtmax, - dP/ dtmax, Vce - 5kPa and Vpm were increased in the rats suffering from acute myocardial ischemia induced by pituitrin; MAP and L\IDP were decreased; IT was shortened, and meanwhile HR was lowered. The effects mentioned above were dose - dependent. Conclusion : FDPM can improve hemodynamics of myocardial ischemia rats induced by pituitrin.