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溴氯海因杀灭微生物效果与稳定性的试验观察 被引量:35

EXPERIMENTAL OBSERVATION ON GERMICIDAL EFFICACY AND STABILITY OF BROMOCHLOROHYDANTOIN
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摘要 溴氯海因(1-氯-3-溴-5,5-二甲基乙内酰脲)为含有效氯44.36%的白色粉末。为了解其杀灭微生物效果与贮存稳定性,进行了载体杀灭微生物试验与用碘量法测其有效氯含量.结果,含有效氯1000mg/L的溴氯海因溶液作用60min,对布片上枯草杆菌黑色变种芽胞的杀灭率>99.90%;含有效氯100mg/L者作用5min,对布片上金黄色葡萄球菌、大肠杆菌的杀灭率均达100%; 含有效氯400mg/L者作用5min,对布片上白色念珠菌的杀灭率亦达100%;含有效氯1000mg/ L者作用45min,可将不锈钢片表面 HBsAg抗原性完全破坏。小牛血清对其杀菌效果有一定影响。其粉剂在54℃放置14d,有效氯下降率为1.24%。该剂属于溶液杀菌效果受有机物影响,粉剂贮存较稳定的消毒剂。 Bromochlorohydantoin(1-chloro-3-bromo-5,5-dimethylhydantoin) is a white powder containing 44.36% of available chlorine. In order to know its germicidal effcacy and storing stability, carrier germicidal test was carried out and iodometric method was used to measure its available chlorine content. The results showed that the killing rate of spores of Bacillus subtilis var. niger on the cloth strip exposed to the bromochlorohydantoin solution con- taining available chlorine 1000 mg/L for 60 min was >99.90%, that of Staphylococcus aureus and Escherichia coli on the cloth strip exposed to the solution containing available chlorine 100 mg/L for 5 min was 100% and that of Candida albicans on the cloth strip ex- posed to the solution containing available chlorine 400 mg/L for 5 min was also 100%. The solution containing available chlorine 1000 mg/L with a 45 min contact time could destroy completely the antigenicity of HBsAg on the surface of stainless steel coupon. The calf serum had certain influence on its germicidal effcacy. The available chlorine content of its powder decreased by 1.24% after storing at 54℃ for 14 days. This disinfectant belongs to the disin- fectants with germicidal efficacy of the solution being influenced by organic substances and the powder form being relatively stable during storage.
作者 刘继敏 赵勇
出处 《中国消毒学杂志》 CAS 2001年第4期218-222,共5页 Chinese Journal of Disinfection
关键词 氯溴二甲基乙内酰脲 微生物 杀菌试验 消毒剂 chlorobromodimethyl hydantoin sporicide Bacillus subtilis var. niger Staphylococcus aureus Escherichia coli HBsAg stability
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