胺碘酮治疗心律失常临床疗效

The effect of Amiodaronum in the treatmeat of arrythmia.

目的 评价小剂量胺碘酮抗心律失常的长期疗效及安全性。方法 本文采用前瞻性及回顾性分析 ,根据 15 1例病人心电图及动态心电图结果确诊心律失常类型 ,并随机分为治疗组 (胺碘酮组 ) 70例 ,对照组 (心律平组 ) 85例 ,治疗 3～ 12月 ,按全国统一标准评价临床疗效。结果 治疗组总有效率 85 .71% ,显效率 5 7.14 % ( 4 0 / 70例 ) ,有效率 2 8.5 7%( 2 0 / 70例 ) ,副反应率 14 .2 9% ( 10 / 70例 )。对照组总有效率 4 7.0 6% ,显效率 17.65 % ( 15 / 85例 ) ,有效率 2 9.4 1% ( 2 5 / 85例 ) ,副反应率 17.65 %。治疗组疗效明显优于对照组 ,P<0 .0 5。结论 小剂量胺碘酮对不同病因引起的心律失常的控制较心律平更为安全有效。

Objective Evaluate the long time effect and safety of small dose amiodaronum in the treatment of arrythmia.Methods The prospective and ratrospective analysis was used and 150 cases who were confirmed diagnoses of arythmia by ECG and Holter were divided into treatment group (amiodaronum group,70 cases) and contrast group (propafenone group,85 cases).The two group were treated for 3 to 12 months and evaluated by the national standard).Results In the treatment group,the total effective rate,apparent effective rate and the effective rate were 85.71%,57.14%(40 in 70 cases)and 28.57%(20 in 70 cases )respectively.The side effect rate was 14.29%(10 in 70 cases).In contrast group,the total effective rate,apparent effective rate and the effective rate were 47.06%,17.65%(15 in 85 cases) and 29.41% (25 in 85 cases) respectively,The side effect rate was 17.65%(15 in 85 cases).The effects in treatment group were higher than the contrast group, P <0.05.Conclusion Amiodarone is more effective and safe than propafenone in the control of different causes of arrythmia.