奥扎格雷钠对高凝状态者凝血和纤溶指标的影响

The effect of ozagrei sodium on index of coagulation and fibrinolysis in patients with hypercoagulability.

目的 :观察奥扎格雷钠对高凝状态患者凝血和纤溶指标的影响。方法 :对 38例高凝状态患者 ,用奥扎格雷钠 16 0mg/d ,加入 5 %葡萄糖或生理盐水 2 0 0～ 5 0 0ml中静脉滴注 ,每日 2次 ,14d为 1疗程。用药前后检测血管性血友病因子 (vWF) ,可溶性纤维蛋白单体复合物 (SFMC) ,血小板膜颗粒蛋白 140 (GMP 140 ) ,抗凝血酶Ⅲ (AT Ⅲ )活性 ,D 二聚体 ,组织纤溶酶原激活物 (t PA) ,纤溶酶原激活物抑制物 I(PAI I) ,纤维蛋白原 (Fg)。 结果 :奥扎格雷钠对GMP 140、vWF、SFMC、PAI I、D 二聚体有显著抑制作用 (P <0 .0 1) ,对AT Ⅲ有明显提高作用 (P <0 .0 5 )。结论

Objective:To discuss the effect of index of coagulation and fibrinolysis with hypercoagulability. Method:38 patients with hypercoagulability were treated by ozagrei Sodium. We examined vWF,SFMC,GMP-140,activity of ATⅢ,D-dimer,t-PA,PAI-I and Fg before and after treatment. Result:Ozagrei sodium remarkably inhibited SFMC,PAI-I and D-dimer (P< 0.01 ),on the contrary it increased of t-PA and ATⅢ.Conclusion:Ozagrei Sodium can improve patient′s hypercoagulability.