摘要
目的 探讨高血压大鼠脑血管早期病理改变与脑微动脉瘤形成的关系。方法 建立肾性高血压大鼠模型 ,应用光镜及电镜观察脑血管组织学改变。结果 实验组发现 2个肉眼可见的动脑瘤及 10个镜下早期动脉瘤。动脉分叉部内膜垫的变化与动脉瘤的病理改变程度有密切关系 ,动脉瘤形成早期即有内皮细胞损伤。
Objective To investigate relationship between early histologic changes of cerebral arteries and cerebral microaneurysmal formation induced by renal hypertension in rats.Methods At first, the posterior branches of bilateral renal arteries were cogulated. One week later, the left common carotid artery was coagulated and cut. Subsequently, 1% saline solution was substituted for drinking water to enhance the hypertension. Four months later, the animals were sacrificed, the circle of wills and its major branches were dissected and examined carefully under dissecting microscope. The tissues were routinely observed under light and electronic microscopy.Results Two apparent aneurysms and ten small aneurysmal protrusions were observed in experimental animals, most aneuysms were located at the ACA branching. Preaneurysmal change revealed the intimal pad getting blunt or disappear, and the internal elastic lamina was splitted into layers or fragmented, endothelial cells became hypertrophied or vacuolated. The smooth muscle cells varied in size and shape, and disorderly arranged, electronic density decreased in cytoplasm, especially, mitochondria of smooth muscle cells, indicating energic metablic disturbance of these cells. Fibroblast cells increased.Conclusions There is a close relationship between the changes of intimal pad and the aneurysmal formation. The initial injury of endothelial cells followed by energic metablic disturbance of smooth muscle cells, which resulting in degeneration or disrupture of the internal elastic lamina, may contribute to aneurysmal formation under stress of hypertension.
出处
《中华神经外科杂志》
CSCD
北大核心
2001年第6期371-374,共4页
Chinese Journal of Neurosurgery
基金
1998年河北省科委资助项目