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复方柴胡汤加减对大鼠酒精性肝损伤形态学和线粒体的定量研究

Morphology Observation and Mitochondria of Quantitative Study about the Protection of Herbal Medicine Water of Buplenrum Chinensis to Alcoholic liver Injury
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摘要 目的探讨中药复方对酒精性肝损伤的防护作用。方法形态学观察(光镜,电镜)应用MPIAS-500病理图文分析系统做线粒体定量分析(面积,周长,等效直径,平均光密度)。结果光镜损伤组肝细胞破坏明显,呈气球样变,有酒精小体。汇管区有炎细胞浸润。而防治组与正常组相似,肝小叶排列规则,细胞体积大,分界清晰。电镜损伤组细胞核不规则,胞质疏松,含大量脂滴。而防治组与正常组相似,核大而规则,含丰富细胞器,无或少量脂滴。线粒体各指标损伤组与防治组差异显著(P<0.01)。结论本中药复方对酒精性肝损伤具有一定的防护作用。 Objective To study the protection of Herbal Medicine Water of Buplenrum Chinensis to alcoholic liver injury. Methods Morphology was observated with Light - Microscope(LM) and Electric - Microscope (EM);The quantitative analysis of mitochondria about area, round length, equal diameter, average light density was done with MPIAS - 500. Results LM:The liver cells of injury group were destroyed which were similar to balloon. There were Mallory Body in liver cell. The portal area were soaked by white cell. The structures of protection group were similial to normal group. Hepatic lobule arrange regular, liver cell volume was larger and boundary clearly. EM: Nucleus of the liver cell of injure group were irregular, cytoplasm was loose, there were a lot of fat drop in cell. About the protection group, nucleus were larger and regular, there were abundant organelles, there weren' t fat drop. There were significant difference between protection group and injure group(P< 0. 01 ). Conclusions Herbal Medicine Water of Buplenrum Chinensis can protect the alcoholic liver injury.
出处 《齐齐哈尔医学院学报》 2001年第1期3-4,共2页 Journal of Qiqihar Medical University
关键词 酒精性肝损伤 复方柴胡汤 形态学 定量研究 Alcoholic liver injury Herbal Medicine Water of Buplenrum Chinensis Morphology Quantitative analysis of mitochondria
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