摘要
我们设计和合成了α-CAO的N-烯丙基类似物,N-烯丙基-7α-二(β—氯乙基)氨基—6,14-乙烯撑基—去甲四氢奥利文(简称A-α-CAO)。整体和离体试验研究表明它具有较高的受体亲和力,是一个新型的广谱阿片受点不可逆配体,且对不同受体亚型表现不同作用。未见成瘾倾向。
We have designed and synthesized an N-allyl analog of α-CAO, named N-allyl-7α-N, N-bis(β-chloroethyl)amino-6,14-endoetheno-tetrahydronororipavine (A-α-CAO). All results of in vivo and in vitro studes on A-α-CAO indicate that the new compound possesses high affinity for opioid receptors and is a novel irreversible ligand for all types of opioid receptors. The effects of A-α-CAO on different receptor types, however, are different. No tendency of dependence has been observed.
出处
《上海医科大学学报》
CSCD
1991年第6期478-480,共3页
Journal of Fudan University(Medical Science)
关键词
阿片受体
A-α-CAo
激动剂
止痛
opiate receptor
partial agonist
irreversible ligand
analgesics
A-α-CAO