摘要
尽管胞二磷胆碱(CDPC)对实验性缺血性脑损害有肯定的保护作用,但其临床疗效存在着争议。本文观察50例经 CT 证实的急性脑梗塞,在发病后11天内随机双盲接受CDPC(500mg/d,静滴)或安慰剂治疗10～14天。结果显示:CDPC 未能促进神经症状及体征、肢体肌力、日常生活自理能力等方面的恢复。作者强调随机双盲对照法,并分析了 CDPC 无效的原因。
The clinical effectiveness of cytidine diphosphate choline(CDPC)in patients withcerebral infarction is controversial,though its effects for experimental cerebral ischemiaare well established.In this report,50 cases of acute cerebral infarction confirmed by com-puterized tomographic scan were randomly assigned to receive CDPC(500mg/day,iv)orplacebo for 10-14 days within 11 days after ictus.The results indicated that CDPC can-not promote the recovery of neurologic symptoms and signs,muscle power and activitiesof daily life.The authors emphasize the importance of randomized,double-blind and control-led method,and the causes of ineffectiveness of CDPC are discussed.
出处
《上海医学》
CAS
CSCD
北大核心
1991年第3期138-140,共3页
Shanghai Medical Journal
