健脾降脂灵对高脂血症大鼠血脂的影响

Influences of Jianpi Jiangzhi Lin(健脾降脂灵) on blood lipids in rats with hyperlipemia

目的 :观察健脾降脂灵对实验性高脂血症大鼠血脂的影响。方法 :采用正常及食饵性高脂血症大鼠模型 ,观察健脾降脂灵对正常大鼠和高脂血症大鼠血脂水平的影响。结果 :健脾降脂灵对正常大鼠血清总胆固醇(TC)、甘油三酯 (TG)有降低作用 ,对高密度脂蛋白胆固醇 (HDL C)有升高作用 ,但与对照组比较无显著意义 (P均 >0 .0 5 ) ;而对实验性高脂血症大鼠 TC、TG及低密度脂蛋白胆固醇 (L DL C)均有显著降低作用 (P<0 .0 1或 P<0 .0 5 ) ,对 HDL C有显著升高作用 (P<0 .0 5 )。结论 :健脾降脂灵对正常大鼠及实验性高脂血症大鼠血脂均有调节作用 。

Objective:To observe the effect of Jianpi Jiangzhi Ling(健脾降脂灵) in treatment of experimental hyperlipemia Wistar rats.Methods:The curative effect of Jianpi Jiangzhi Ling on blood lipids in normal and hyperlipemia Wistar rats were observed.Results:After Jianpi Jiangzhi Ling treatment,the level of total cholesterol(TC),triglycerides(TG) were decreased,highdensity lipoproteincholesterol(HDLC) was increased,there were no significant differences comparing with control group (all P >0 05).The level of TC,TG,lowdensity lipoprotein cholesterol(LDLC) were lower significantly in hyperlipemia Wistar rats ( P <0 01 or P <0 05),and the level of HDLC were significantly higher ( P <0 05) after Jianpi Jiangzhi Ling treatment.Conclusions:Jianpi Jiangzhi Ling may regulate the level of blood lipid in normal and hyperlipemia Wistar rats.The effect is more significantly in hyperlipemia rats than in normal rats.