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胃癌组织中基质分解素-1基因表达的研究 被引量:4

Expression of stromelysin-l gene in tissue of gastric carcinoma
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摘要 目的 了解基质分解素-1(MMP_3)基因在胃癌组织的表达水平。方法 43例胃癌患者胃镜下取癌组织及正常胃粘膜,提取组织总RNA,用逆转录共扩增定量PCR方法测定MMP_3基因表达水平。结果 胃癌组织MMP_3,基因表达水平(2.02±0.34)明显高于正常胃粘膜组织(0.63±0.10,P<0.01),局部淋巴结受累者MMP_3基因表达水平(2.46±0.39)明显高于局部淋巴结未受累者(1.60±0.30,P<0.01)。结论 基质分解素-1在胃癌的浸润、转移中可能起重要作用。 Objective To investigate expression of stromelysin-1 ( MMP3) gene in tissues of gastric carcinoma. Methods 43 patients with stomach carcinoma were selected in this study. Cancerous tissue and normal gastric mucosa tissue were obtained under gastroscopy. Total RNA was isolated and expression of MMP3 gene was measured by reverse transription polymerase chain reac-tion( RT-PCR). Results Expression of MMP3 gene was stronger in gastric cancerous tissue(2. 02 ?
出处 《华北国防医药》 2002年第1期11-12,共2页 Medical Journal of Beijing Military Region
关键词 胃肿瘤 基质溶解素1 肿瘤转移 基因表达 逆转录共扩增定量PCR法 Tumor, of stomach Stromelysin-1 Matastasis
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  • 1Chao Xu Zheng~1 Wen Hua Zhan~1 Ji Zong Zhao~2 Dong Zheng~3 Dong Ping Wang~1 Yu Long He~1 Zhang Qing Zheng~1 ~1Department of General Surgery,~2Laboratory of Surgery,~3Department of Medicine,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,Guangdong Province,ChinaDr.Chao Xu Zheng now working as a surgeon and lecturer in the Department of General Surgery,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,who is a Ph.D.student,having 7 papers published..The prognostic value of preoperative serum levels of CEA,CA19-9 and CA72-4 in patients with colorectal cancer[J].World Journal of Gastroenterology,2001,7(3):431-434. 被引量:25
  • 2赵贤宝,李文亮,陈明清.基质金属蛋白酶与肿瘤血管形成关系的研究进展[J].国外医学(肿瘤学分册),2003,30(6):431-433. 被引量:5
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