氟伐他汀与丁苯酞软胶囊联合治疗急性脑梗死疗效观察

Efficacy of fluvastatin combined with butylphthalide soft capsule on acute cerebral infarction

目的探讨氟伐他汀与丁苯酞软胶囊联合治疗急性脑梗死的临床疗效。方法选择2018年1～7月期间咸阳市第一人民医院神经内科收治的90例急性脑梗死患者为研究对象,根据随机数表法分为对照组和观察组,每组45例,对照组采用抗血小板等常规治疗,同时应用氟伐他汀治疗,观察组在此基础上联合应用丁苯酞治疗,疗程14 d。比较两组患者治疗前后的美国国立卫生院神经功能缺损量表(NIHSS)评分、Barthel指数(BI)评分的变化,以及血清超敏C反应蛋白(hs-CRP)、白细胞介素-6 (IL-6)水平的变化,同时比较临床疗效。结果治疗后,观察组患者的NIHSS及BI评分分别为(8.89±2.34)分、(64.57±17.67)分,明显优于对照组的(12.13±2.69)分、(55.69±15.48)分,差异均有统计学意义(P<0.05);观察组患者治疗后的血清hs-CRP、IL-6水平分别为(11.36±3.21) mg/L、(19.54±6.18) ng/L,明显低于对照组的(14.73±3.88) mg/L、(24.37±7.02) ng/L,差异均具有统计学意义(P<0.05);观察组患者的治疗总有效率为84.84%,明显高于对照组的68.89%,差异具有统计学意义(P<0.05)。结论氟伐他汀联合丁苯酞软胶囊治疗急性脑梗死可以有效降低患者的血清炎症因子水平,改善患者的神经功能缺损及提高日常生活能力。

Objective To investigate the clinical efficacy of fluvastatin combined with butylphthalide soft capsule in the treatment of acute cerebral infarction.Methods A total of 90 patients with acute cerebral infarction treated in Department of Neurology,the First People's Hospital of Xianyang City,from January 2018to July 2018 were selected and divided into a control group and an observation group according to the random number table method,with 45cases in each group.The control group received routine antiplatelet therapy and fluvastatin treatment.The observation group was treated in combination with butylphthalide on this basis of above treatment;the course of treatment was 14days. The National Institutes of Health Neurological Deficit Scale (NIHSS)score,Barthel index (BI)score,serum hypersensitive C-reactive protein (hs-CRP),and interleukin-6(IL-6) levels were compared between the two groups before and after treatment,and the clinical effects were compared.Results After treatment,the NIHSS and BI scores in the observation group were (8.89±2.34)and (64.57±17.67),respectively,which were significantly better than (12.13±2.69)and (55.69±15.48)in the control group,and the differences were statistically significant (P<0.05);the serum hs-CRP and IL-6 levels in the observation group were (11.36±3.21)mg/L and (19.54±6.18)ng/L,respectively,significantly lower than (14.73±3.88)mg/L and (24.37±7.02)ng/L in the control group,the differences were statistically significant (P< 0.05).The total effective rate of the observation group was 84.84%,significantly higher than that of the control group (68.89%),P<0.05.Conclusion Fluvastatin combined with butylphthalide soft capsule in the treatment of acute cerebral infarction can effectively reduce the level of serum inflammatory factors,improve neurological deficits and improve the ability of daily living.