摘要
目的探讨疏风宣肺止咳法与氟替卡松吸入联合治疗感染后咳嗽的临床疗效及对患者免疫功能的影响。方法感染后咳嗽患者130例,按随机数字表法分为观察组与对照组,各65例。对照组给予单纯氟替卡松吸入治疗(100μg/次,2次/d),观察组则在对照组的基础上联合疏风宣肺止咳法治疗,1剂/d,2次/d。连续治疗1周后,对比两组临床疗效及不良反应发生率情况,采用免疫比浊法检测两组治疗前后血清Ig E水平变化情况,采用流式细胞仪测定两组治疗前后CD3+、CD4+、CD8+水平变化情况。结果观察组治疗总有效率为93.84%,明显优于对照组的81.53%(P <0.05)。观察组治疗后Ig E(113.71±40.00)ng/m L明显低于对照组(198.20±57.20)ng/m L(P <0.01)。观察组治疗后CD3+、CD4+、CD4+/CD8+水平分别为(68.69±7.35)%、(39.40±6.00)%、(1.83±0.34)%,明显高于对照组的(61.53±7.00)%、(32.46±5.00)%、(1.10±0.30),CD8+水平(21.10±3.00)%明显低于对照组(26.25±3.00)%(P <0.05);观察组不良反应发生率(4.62%)与对照组(6.15%)对比差异无统计学意义(P> 0.05)。结论针对感染后咳嗽患者,给予疏风宣肺止咳法与氟替卡松吸入联合治疗可提高细胞免疫功能,改善局部病理状态,提升疗效。
Objective To investigate the clinical efficacy of Shufeng Xuanfei Zhike method and fluticasone inhalation in the treatment of post-infection cough and its effect on immune function.Methods 130 cases of postinfection cough patients were collected and divided into observation group and control group according to random number table,65 cases each.The control group received inhalation of fluticasone alone (100ug/time,2 times/d),on the basis of the control group,the observation group was treated with the method of Shufeng Xuanfei Zhike 1 dose/ d,2 times/d.After one week of continuous treatment,the clinical efficacy and incidence of adverse reactions were compared between the two groups.The changes of serum IgE levels before and after treatment were detected by immunoturbidimetry.The levels of CD3^+,CD4^+,CD8^+ before and after treatment were measured by flow cytometry. Results The total effective rate of the observation group was 93.84%,which was significantly better than that of the control group (81.53%)(P <0.05).IgE (113.71±40.00)ng/mL was significantly lower in the observation group than in the control group (198.20±57.20)ng/mL (P <0.01).The levels of CD3^+,CD4^+、CD4^+/CD8^+ in the observation group were (68.69±7.35)%,(39.40±6.00)%,(1.83±0.34)%,respectively,which were significantly higher than those in the control group (61.53±7.00)%,(32.46±5.00)%,(1.10±0.30)%,respectively,but the level of CD8^+ (21.10±3.00)% was significantly lower than that in control group (26.25±3.00)%(P<0.05).The incidence of adverse reactions in the observation group was 4.62% and the control group was 6.15%.The difference was not statistically significant (P>0.05).Conclusion For patients with post-infection cough,the combination of Shufeng Xuanfei Zhike method and fluticasone inhalation can improve cellular immune function,improve local pathological state,promote curative effect,and have fewer adverse reactions.This treatment is worth popularizing in clinic.
作者
夏欣田
XIA Xintian(The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China)
出处
《吉林中医药》
2018年第12期1398-1401,共4页
Jilin Journal of Chinese Medicine
基金
广东省中医药局科研课题(20142045)
关键词
疏风宣肺止咳法
氟替卡松
感染后咳嗽
Shufeng Xuanfei Zhike method
fluticasone
post-infection cough