检测炎性因子(IL-6、TNF-α)、皮质醇及5-羟色胺(5-HT)对临床评价抑郁症患者病情发展及预后的作用

Objective to investigate the role of inflammatory factors(IL-6,TNF-a),cortisol and 5-serotonin(5-HT) in the clinical evaluation of the development and prognosis of patients with depression

目的探讨检测抑郁症患者炎性因子和皮质醇及5-羟色胺(5-HT)对其病情及预后的评价作用。方法选取医院收治的76例抑郁症患者作为本次研究观察组,另选取医院76例同期入院健康体检的正常健康者为对照组。分别检测两组受检对象炎性因子(IL-6、TNF-α)、皮质醇和5-羟色胺(5-HT)水平,采用汉密尔顿抑郁表(HAMD)评分其抑郁症状,并分析患者病情程度与其临床各项指标间的相关性。结果观察组患者IL-6、TNF-α、皮质醇及5-HT水平明显高于对照组,P<0.05;随着抑郁症患者病情的发展,其IL-6、TNF-α、皮质醇水平明显升高,而5-HT水平不断下降,P<0.05。结论检测抑郁症患者炎性因子和皮质醇及5-HT水平可有助于评价其病情及预后,为临床治疗方案制定及预后判断提供参考。

Objective To discuss the effects of inspecting depressive patients' inflammatory factor,cortisol and 5-HT levels for evaluating their disease states and prognosis. Method 76 patients with depression admitted to the hospital were selected as the study observation group,and 76 normal healthy persons who were admitted to the hospital for the same period were selected as the control group. The levels of inflammatory factors(IL-6,TNF-α),cortisol and serotonin(5-HT)were measured in two groups. The depression symptoms were scored by Hamilton Depression Table(HAMD),and the patient's condition was analyzed. Correlation between clinical indicators. Results The levels of IL-6,TNF-α,cortisol and 5-HT of observation group's patients are apparently higher than that of control group's patients,P<0.05;when depressive patients got worse,their IL-6,TNF-α and cortisol levels rose apparently,while their 5-HT level dropped continuously,P<0.05. Conclusion Inspecting depressive patients' inflammatory factor,cortisol and 5-HT levels can be helpful for evaluating their disease states and prognosis and providing reference for the drafting of clinical treatment scheme and prognosis judgment.