中医综合康复护理对脑梗死偏瘫患者内皮细胞功能及肢体功能的影响

Effect of comprehensive rehabilitation nursing on endothelial cell Function and limb function in cerebral infarction patients with hemiplegia

目的 探讨中医综合康复护理对脑梗死偏瘫患者内皮细胞功能及肢体功能的影响。方法 将2017年2-8月收治的70例脑卒中梗死偏瘫患者采用随机数字表法分为观察组和对照组,每组35例。对照组采用常规西药治疗+康复训练,观察组在对照组的基础上采用中医综合康复护理,比较2组的临床疗效、神经功能、肢体运功功能,并检测患者的内皮因子—血管内皮素(ET)、一氧化氮(NO)、血清降钙素基因相关肽(CGRP)。结果 观察组的总有效率为91.43%(32/35),高于对照组的68.57%(24/35),差异有统计学意义(Z=5.887,P=0.041)。观察组干预后的NO、CGRP分别为(68.21 ± 15.46)、(48.29 ± 9.04)mg/L,高于对照组的(56.23 ± 12.35)、(39.86 ± 10.75)mg/L,ET为(56.25 ± 9.71)mg/L,低于对照组的(68.34 ± 11.84)mg/L,差异有统计学意义(t=3.582、3.551、4.771,均P=0.000)。观察组干预后的神经功能缺损程度评分法评分为(8.69 ± 1.66)分,低于对照组的(12.02 ± 1.97)分,上肢及下肢肌力分别为(2.78 ± 0.61)、3.42 ± 0.63)级,好于对照组的(2.26 ± 0.45)、2.84 ± 0.62)级,Fugl-Meyer评分为(78.62 ± 10.33)分,高于对照组的(69.53 ± 8.64)分,差异有统计学意义(t=3.882-7.647,均P=0.000)。结论 中医综合康复护理能够显著提高脑梗死偏瘫患者的临床疗效,促进肢体功能和神经功能的恢复,这可能与其改善血管内皮细胞功能的作用有关。

Objective To explore the effect of comprehensive rehabilitation nursing on endothelial cell function and limb function in patients with cerebral infarction. Methods A total of 70 cerebral infarction patients with hemiplegia treated from February to August 2017 were divided into the observation group and the control group by random digits table method, 35 cases in each group. The control group was treated with conventional western medicine and rehabilitation training. The observation group was adopted the comprehensive rehabilitation nursing of traditional Chinese medicine on the basis of the control group. The clinical efficacy, nerve function and limb function of the two groups were compared, and the endothelium factor endothelin (ET), nitric oxide (NO) and serum calcitonin gene-related peptide (CGRP) of the patients were detected. Results The total effective rate in the observation group and the control group was 91.43% (32/35), 68.57% (24/35), and the difference was statistically significant (Z=5.887, P=0.041). The NO and CGRP in the observation group after intervention were (68.21±15.46) mg/L, (48.29±9.04) mg/L and (56.23±12.35) mg/L, (39.86±10.75) mg/L in the control group, while ET was (56.25±9.71) mg/L in the observation group and (68.34±11.84) mg/L in the control group, and the difference was statistically significant (t=3.582, 3.551, 4.771, P=0.000). The Nerve Function score in the observation group after intervention was (8.69±1.66) points and (12.02±1.97) points in the control group, and the strength of upper and lower limbs was (2.78±0.61), (3.42±0.63) grades, better than (2.26±0.45), (2.84±0.62) grades in the control group, and the score of Fugl-Meyer score was (78.62±10.33) points in the observation group and higher than (69.53±8.64) points in the control group, the difference was statistically significant (t=3.882-7.647, all P=0.000) . Conclusions Comprehensive rehabilitation nursing can significantly improve the clinical effect of cerebral infarction patients with hemiplegia, promote the recovery of limb function and nerve function, which may be related to the effect of improving the function of vascular endothelial cells.