TC、ApoB、hs-CRP水平在T2DM合并亚临床甲状腺功能减退患者血清中的表达水平及临床意义

Study on the Expression of TC、ApoB and Hs-CRP in Patients with Subclinical Hypothyroidism of T2DM

【目的】探讨总胆固醇(TC)、高敏C反应蛋白(hs-CRP)、载脂蛋白B(ApoB)在Ⅱ型糖尿病(T2DM)合并亚临床甲状腺功能减退(SCH)患者血清中的表达水平及临床意义。【方法】选择2015年4月至2018年1月本院诊治的T2DM合并SCH患者140例(观察组);另外选取同期收治的促甲状腺激素 (TSH)水平正常的T2DM患者140例作为对照组。比较两组患者年龄、性别比例、血脂及血清hs-CRP水平;并分析上述指标与甲状腺激素水平的相关性。【结果】观察组患者平均年龄显著大于对照组;女性患者比例显著高于对照组;血清TC、LDL-C、ApoB、hs-CRP水平均显著高于对照组;多因素Logistic回归分析;结果显示TC、LDL-C、ApoB、hs-CRP、TSH水平升高是T2DM患者并发SCH的独立危险因素(均P<0.05)。【结论】与单纯T2DM患者相比;T2DM合并SCH患者脂代谢水平异常;且炎症反应参与血管病变的形成;hs-CRP可作为T2DM患者发生SCH的有效监测指标。

【Objective】 To investigate the expression and clinical significance of total cholesterol (TC), high-sensitivity C-reactive protein (hs-CRP) and apolipoprotein B (ApoB) in the serum of type Ⅱ diabetes mellitus (T2DM) patients with subclinical hypothyroidism (SCH).【Methods】 From April 2015 to January 2018, 140 patients with T2DM combined with SCH were treated in our hospital (observation group) and 140 T2DM patients with normal thyroid stimulating hormone (TSH) were selected as control group. Age, sex ratio, blood lipid and serum hs-CRP levels were compared between the two groups, and the correlation between the above indexes and thyroid hormone level was analyzed.【Results】 The average age, the proportion of female and the level of serum TC,LDL-C,ApoB,hs-CRP of the patients in the observation group were significantly higher than those in the control group. Multivariate Logistic regression analysis showed that the increase of TC,LDL-C, ApoB, hs-CRP,TSH level was an independent risk factor for SCH in T2DM patients (mean P<0.05).【Conclusion】 Compared with the patients with T2DM alone, the level of lipid metabolism is abnormal in patients with T2DM combined with SCH, and the inflammatory reaction is involved in the formation of vascular lesions. Hs-CRP can be used as an effective index for monitoring the occurrence of SCH in patients with T2DM.