3-氯-1-(2-吡啶基)-3,5-二甲基-吡唑-4-乙酰胺基-5-三氟甲基-苯基-1,3,4-噻二唑的合成研究

Study On The Synthesis Of 3-Chlorine-1-(2-pyridin)-3,5-dimethyl-pyrazol-4-acetamide-5-triflluoromethyl-phenyl-1,3,4-thiadiazole

寻找具有较高活性的含1,3,4-噻二唑杂环衍生物。根据活性拼接原理,分别将吡唑,1,3,4-噻二唑引入到同一分子中,用1H NMR 13C NMR将其结构进行表征。所合成的化合物首次被报道。试验表明,该化合物显示出显著的除草活性。可以将其作为先导化合物,设计合成更多的类似物来探索新型、高效低毒和对非靶标生物安全的新型除草剂。

The aim of this paper is to try to find high biological derivatives containting 1,3,4-thiadiazole. Respectively,the pyrazole ring,1,3,4-thiadiazole ring were introduced into the same molecule according to the principle of active group combination,The target structures were characterized by 1H NMR and 13C NMR. The synthesized compounds has been reported foe the first time,The experiment proves the synthesized compounds revealed significant weeding activity.It can act as lesd compounds for designing and synthesizing moer analogues to search for new herbicide with new and high efficacy and low toxicity as well as safety to non-target organisms.