男性肝豆状核变性生殖激素水平临床观察

Clinical Observation of Reproductive Hormone Levels in male Wilson's Disease

目的:观察男性肝豆状核变性患者体内生殖激素水平,为男性肝豆状核变性患者合并生殖损害提供依据。方法:对2018年2—8月就诊于安徽中医药大学第一附属医院脑病科的男性肝豆状核变性患者进行生殖激素系列检查,得出生殖激素结果,进行统计学分析。结果:此次参与观察的100位男性肝豆状核变性患者,总体生殖激素异常率在78%,其中雌二醇、泌乳素、睾酮、孕酮、卵泡刺激素是此次临床观察主要异常指标,此次观察中无黄体生成素异常,其异常率分别是41.3%,13.7%,27.5%,34.5%,10.3%。结论:雌二醇、泌乳素、睾酮、孕酮、卵泡刺激素指标的异常可表现在生殖损害中,在一定程度上可体现出患者的生殖功能水平,相关分泌的不足或过量可导致生殖损害,此次观察为男性肝豆状核变性患者合并生殖损害提供临床依据。

Objective:To observe the level of reproductive hormone in male patients with Wilson's disease and to provide evidence for the combined reproductive damage in male patients with Wilson's disease.Methods:From February 2018 to August 2018,the patients with male hepatolenticular degeneration in the department of Encephalopathy,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine were examined for reproductive hormones.The results of reproductive hormones were obtained and statistical analysis was performed.Analyze and evaluate The level of reproductive hormone in male Wilson's disease.Resuhs:The total reproductive hormone abnormality rate was 78% in 100 male patients with Wilson's disease,and estradiol,prolactin,testosterone,progesterone and follicle stimulating hormone were the main abnormal indicators of this clinical observation.There was no luteinizing hormone abnormality in this observation,and the abnormal rates were 41.3%,13.7%,27.5%,34.5%,10.3%,and abnormalities in estradiol,prolactin,testosterone,progesterone,and follicle stimulating hormone were observed.In reproductive damage,the reproductive function level of the patient can be reflected to a certain extent,and the lack or excess of related secretion can lead to reproductive damage.This observation provides a clinical basis for the combined reproductive damage in male patients with Wilson's disease.