163例临床药物不良反应报告分析

An analysis of 163 cases with adverse drug reactions

目的:对我院1998年1月至2001年6月自发呈报的163例药物不良反应(ADR)报告进行分析。方法:采用描述性研究方法对ADR报告进行分类。结果:涉及药物124种,单一用药85例,合并用药78例;ADR程度分级,重度22例,中度82例,轻度59例;因果关系评定为肯定9例,很可能114例,可能36例,可疑4例;对症治疗133例,未进行特殊处理30例;痊愈130例,好转31例,死亡2例;使原患病程延长12例,病情加重3例。抗生素引起的ADR居首位,为 53.89％;ADR中引起皮肤及附件损害最多,为71.34％。结论:应加强ADR知识的宣传,将药品不良反应监测放在与治疗作用同等重要的位置上,尽可能避免或减少ADR的重复发生,达到用药有效安全的目的。

Objective: To analyze ADR reports of 163 cases from January 1998 to June 2001 in our hospital. Method: The ADR reports were classified by a descriptive research method.Results: 124 drugs were involved in these reports. In 85 cases only one drug was used and in other 78 cases more than one drug were in combination. As for intensity of ADR, there were severe 22, moderate 82, mild 59; and according to causality of ADR, certain 9, probable 114, possible 36, unlikely 4. 133 patients were symptomati-cally treated, the remaining not. 130 patients fully recovered, 31 turned for the improvement and 2 died. The leading cause of ADR was antibiotics (53.89% ) . Impairment of skin and its appendages was most commonly experienced (71.34% ) .Conclusion: Great concerns should be attached to the ADR monitoring in keeping abreast of the medical treatment in order to use the drugs safely and effectively.