摘要
目的:研究不同剂量活血渗湿方的抗肝纤维化作用。方法:采用40%四氯化碳给大鼠皮下注射.制备肝纤维化模型,以高、中和低剂量活血渗湿方干预,并与γ-干扰素对照。测定肝功能、血清透明质酸,并通过光镜观察肝组织病理变化和纤维化程度。结果:活血渗湿方高、中、低剂量组均可使肝功能改善、血清透明质酸显著降低、肝组织纤维化程度明显改善。但各剂量组之间疗效比较没有统计学差异(P>0.05)。结论:不同剂量活血渗湿方抗肝纤维化作用相似。
Objective: To investigate the effect of the various does treatment groups Huoxue ShenShi Fang (HXSSF) on hepatic fibrosis in rats. Methods: The rat hepatic fibrotic model was induced by the subcutaneous injection of 40% CC14. The treatment groups of HXSSF were divided into high does group, medium group and low does group. Compared with interferon-7,liver function and serum hyaluronic acid were determined. Histopathological changes and degrees of fibrosis were examined by optical microscopy. Results: It was found that in HXSSF treatment groups liver f unc-tons was improved, and serum hyaluronic acid significantly reduced, at same time the degrees of fibrosis were reduced: But there was no noticeable difference among the HXSSF treatment groups. Conclusions: There was no significant difference among the anti-fibrotic effect of various doese treatment groups of HXSSF.
出处
《中西医结合肝病杂志》
CAS
2002年第2期89-91,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
浙江省自然科学基金(399004)
浙江省中医药科研基金(2000 C10)