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活血渗湿方抗肝纤维化的量效关系 被引量:2

Experimental Reasearch of Huoxue Shenshi Fang to Prevent Hepatic Fibro-sis in Rats
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摘要 目的:研究不同剂量活血渗湿方的抗肝纤维化作用。方法:采用40%四氯化碳给大鼠皮下注射.制备肝纤维化模型,以高、中和低剂量活血渗湿方干预,并与γ-干扰素对照。测定肝功能、血清透明质酸,并通过光镜观察肝组织病理变化和纤维化程度。结果:活血渗湿方高、中、低剂量组均可使肝功能改善、血清透明质酸显著降低、肝组织纤维化程度明显改善。但各剂量组之间疗效比较没有统计学差异(P>0.05)。结论:不同剂量活血渗湿方抗肝纤维化作用相似。 Objective: To investigate the effect of the various does treatment groups Huoxue ShenShi Fang (HXSSF) on hepatic fibrosis in rats. Methods: The rat hepatic fibrotic model was induced by the subcutaneous injection of 40% CC14. The treatment groups of HXSSF were divided into high does group, medium group and low does group. Compared with interferon-7,liver function and serum hyaluronic acid were determined. Histopathological changes and degrees of fibrosis were examined by optical microscopy. Results: It was found that in HXSSF treatment groups liver f unc-tons was improved, and serum hyaluronic acid significantly reduced, at same time the degrees of fibrosis were reduced: But there was no noticeable difference among the HXSSF treatment groups. Conclusions: There was no significant difference among the anti-fibrotic effect of various doese treatment groups of HXSSF.
出处 《中西医结合肝病杂志》 CAS 2002年第2期89-91,共3页 Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金 浙江省自然科学基金(399004) 浙江省中医药科研基金(2000 C10)
关键词 量效关系 肝纤维化 活血渗湿方 血清透明质酸 动物模型 中医药疗法 Hepatic Fihrosis Huoxue Shenshi Fang Serum Hyaluronic Acid Animal Model
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