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通痹灵治疗强直性脊柱炎临床疗效评价 被引量:24

Effect of Tongbiling for Ankylosing Spondylitis
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摘要 [目的]评价通痹灵治疗活动期强直性脊柱炎(AS)的临床疗效、毒副反应。[方法]采用随机对照单盲双模拟的方法,将69例活动期 AS分为通痹灵治疗组(36例)和消炎痛对照组(33例)。通痹灵组口服通痹灵ⅠA,每次 6片,每天 3次;消炎痛组口服消炎痛(通痹灵ⅡA),每片舍消炎病25mg,每次6片,每天3次。[结果]①总有效率两组间无显著性差异(P>0.05),但通痹灵组控显率优于消炎痛组(P<0.01)。②两组治疗前后疼痛积分、晨僵时间和指地距离改善明显P<0.01或P<0.05),扩胸度和枕墙距均无改善(P>0.05)。通痹灵组关节肿胀积分、Schober试验、整体功能、实验指标(ESR、CRP、PLT、IgG、IgA、IgM)和骶髂关节影像积分均有明显改善(P<0.01);消炎痛组关节肿胀积分、整体功能、实验指标和骶髂关节影像积分无改善(P>0.05)。通痹灵组改善肿胀积分、晨僵时间、指地距离、整体功能和实验指标(除CRP外)优于消炎痛组(两组治疗后比较,P<0.01或P<0.05)。③通痹灵组未发现明显不良反应。[结论]通痹灵对活动期AS具有改善临床症状、体征和实验指标的作用,且对AS骨质损害具有保护作用,未发现不良反应。 To evaluate the therapeutic effect of Tongbiling for ankylosing spondylitis (AS) and to study its side and toxic effects. [Methods] Randomized controlled and single - blind double - mimic trial was applied in 69 cases of AS. The cases were allocated to two groups. Group A ( n = 36) were treated with Tongbiling I A, 6 tablets each time, three times per day and Group B ( n = 33) with Tongbiling Ⅱ A (containing indomethacin 25mg) . [Results] The difference of total effective rate in the two groups was not significant (P > 0.05), but the effective rate of symptom relief in Group A was superior to that in Group B (P<0.01). The pain scoring, time of morning stiffness, middle - finger -to - floor distance were improved after treatment in the two groups (P < 0.05 or 0.01) while chest expanding activity and occiput - to - wall distance were not improved ( P > 0.05). Joint swelling, Schober test, general function, laboratory test (ESR, C - reactive protein, platelet count, IgG, IgA and IgM) and scoring of X - ray image of sacra - iliac joint differ significantly after treatment in Group A (P<0.01) while not significant in Group B ( P > 0.05). The improvement of the above indexes except C - reactive protein in Group A was superior to that in Group B ( P < 0.05 or 0.01). No obvious adverse reaction was found in Group A. [Conclusion] Tongbiling can improve the symptoms, signs and laboratory indexes of AS, and can prevent AS patients from bone destruction.
出处 《广州中医药大学学报》 CAS 2002年第1期8-11,共4页 Journal of Guangzhou University of Traditional Chinese Medicine
基金 广东省中医药管理局资助课题(编号:98343)
关键词 通痹灵 治疗 强直性脊柱炎 临床疗效 SPONDYLITIS,ANKYLOSING/TCD therapy SPONDYLITIS,ANKYLOSING/immunology SPONDYLITIS,ANKYLOSING/radiography TONGBILING/therapeutic use TONGBILING/adveree effects GUIZHI SHAOYAO ZHIMU DECOCTION/therapeutic use
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