家族性腺瘤性息肉病癌变危险因素分析

A clinical study on risk factors of colorectal cancer from familial adenomatous polyposis

目的探讨家族性腺瘤性息肉病(FAP)相关性结直肠癌及其癌变危险因素,为监测预防FAP癌变提供依据。方法收集我院确诊的65例FAP患者,根据患者是否发生癌变,分为FAP癌变组(35例)与未癌变组(30例),统计分析FAP相关性结直肠癌发生的危险因素。结果在65例FAP患者中,35例患者经病理确诊发生癌变,癌变率为53.85%。发病年龄、腺瘤数量、腺瘤大小及腺瘤组织学类型是影响FAP癌变的相关因素(P<0.05),且和癌变呈显著正相关。结论 FAP癌变倾向极高,发病年龄、腺瘤数量、腺瘤大小及腺瘤组织学类型是影响FAP癌变的相关因素,与癌变呈正相关。

Objective To investigate the cancerous factors of familial adenomatous polyposis( FAP) and provide the evidence for FAP-associated colorectal cancer( FAP-CRC) screening surveillance and prevention. Methods Sixty-five diagnosed as FAP patients admitted in this hospital were retrospectively evaluated. 65 cases were divided into CRC group and FAP group. Cancerous risk factors of FAP were analyzed. Results Thirty-five patients developed cancers. The incidence of cancer in the FAP patients was 53. 85%. The average cancerous age was( 45. 31 ± 9. 61) years old. Univariate analysis and correlation analysis showed that the age,the number of adenoma,the size of adenoma and the histological type of adenoma were the positive correlative factors of FAP-CRC( P < 0. 05). Conclusion The canceration tendency of FAP is very high. The age,the number of adenoma,the size of adenoma and the histological type of adenoma are the positive correlative factors of FAP-CRC.