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p16、p53和Ki67在宫颈癌中的表达及其临床意义 被引量:28

Expressions of p16,p53 and ki67 in cervical carcinoma and their clinical significance
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摘要 目的探讨p16、p53蛋白及Ki67在宫颈癌中的表达及其临床意义。方法采用免疫组化法检测52例宫颈癌、40例宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)及26例宫颈炎组织中p16、p53蛋白和Ki67的表达水平,并分析三者在宫颈癌组织中表达的相关性。结果 p16、p53蛋白及Ki67在宫颈癌、CIN组织中的阳性表达率均显著高于宫颈炎,差异均有统计学意义(P<0.05)。在宫颈癌组织中,p16、p53蛋白及Ki67的阳性表达均与临床分期、组织学分化程度有关(P<0.05),与年龄、淋巴结转移无关(P>0.05);p16、p53蛋白与Ki67的表达相关(P=0.028,P=0.014)。结论 p16、p53蛋白及Ki67与宫颈癌的发生、发展有关,三者联合检测可作为判断宫颈癌恶性程度和评估预后的重要指标。 Objective To investigate the expressions of p16,p53 and Ki67 in cervical carcinoma and analyze their clinical significance.Methods The expressions of p16,p53 and Ki67 in of 52 patients with cervical carcinoma,40 patients with cervical intraepithelial neoplasia and 13 patients with cervicitis were detected by using immunohistochemistry.The relationships among the three tumor markers were analyzed.Results The expressions of protein p16,p53 and Ki67 in cervical carcinoma and cervical intraepithelial neoplasia were significantly higher than that in cervicitis(P 〈0.05).In cervical carcinoma,there were significant correlations between the expressions and clinical staging and the degree of differentiation(P〈 0.05),but not association with age or lymph node metastasis.Moreover,the expressions of p16 and p53 were correlated with the expression of ki67,respectively(P = 0.028 and P = 0.014,respectively).Conclusion The expressions of p16,p53 and Ki67 were associated with the occurrence and development of cervical carcinoma.Therefore,the three joint detection maybe an index to predict the degree of malignancy and prognosis of cervical carcinoma.
出处 《实用医院临床杂志》 2014年第4期123-125,共3页 Practical Journal of Clinical Medicine
关键词 宫颈癌 P53 P16 KI67 Cervical carcinoma p16 p53 Ki67
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