毛细管气相色谱法测定化妆品中对羟基苯甲酸酯的含量

Determination of Parabens in cosmetics by capillary gas chromatography

目的建立毛细管气相色谱法测定化妆品中的对羟基苯甲酸甲酯和对羟基苯甲酸乙酯。方法采用溶液直接进样法测定,DB-17毛细管柱,FID检测器,分流比10∶1。结果两种防腐剂在10～200μg·mL-1浓度范围内呈良好线性关系,相关系数分别为0.9992、0.9993,两种化合物的加标回收率为95%～98%。结论本法耗时少,分离度高,用标准曲线法测定,方法简单可靠。

OBJECTIVE To establish a method to determine the content of methyl hydroxybenzoate and Ethyl p-Hydrobenzoate by capillary gas chromatography in the cosmetics. METHODS Direct-sample injection method was used with DB-17 capillary、FID detector and split ratio of 10∶1. RESULTS The linear for both of the preservatives was well in range of 10μg·mL- 1～ 200μg·mL- 1,the coefficient correlation was 0.9992 and 0.9993 respectively. The recovery for both of the preservatives was 95% ～ 98%. CONCLUSION The method is easy and robust with high resolution and less time by standard curve method.